Search results for " microbial"
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Best Practices for Selecting a Top-Quality Cell Line
…erted in the right location in the genome with the right dosage, and that the cell line is free from microbial contamination,” he explains.
As a result, a high-quality CAR-T-cell line should n…
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State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
…oach, at least for clinical manufacturing, even to the extent of using CHO where simpler and cheaper microbial bioprocessing could be used. The continued relative lack of single-use microbial bioreac…
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Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
The percent reporting use of microbial has not increased much in 15 years. As discussed in the current annual report, companies prefer to concentrate on one or a few platforms to be applied to as many…
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Single-use Bioreactors Have Reached the Big Time
Cytiva, meanwhile, recently introduced single-use technologies for microbial fermentation. The system is designed to accommodate the demands of microbial cultures, including mass transfer, mixing, and…
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Tools for Continuous Bioprocessing Development
The reactor has been demonstrated in microbial cultivations (10), and has also been shown to work for chinese hamster ovary (CHO) cell cultures as well (11).
• Microfluidics is being used in well p…
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Moving PAT from Concept to Reality
Although a difficult problem to solve, sensors that rapidly measure viral and microbial contamination are needed the most, Braatz states. The long (28-day) time to receive results from cell-culture-ba…
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Cleaning Protein A Resins with 1 M NaOH
The presence of cell culture nutrients in the harvest feed loaded on the capture column also exposes the protein A step to increased risk of microbial contamination. Historically, protein A resins hav…
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Evaluating Surface Cleanliness Using a Risk-Based Approach
Pooling in vessels and piping may lead to microbial blooms, biofilm, and carryover of process and cleaning agent residues. The mixing of the drain solution (heel) can reduce residue deposition on the …
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The New World of Biopharmaceutical Manufacturing
Galliher (Cytiva): In the past five years, new advances include an increase in closed systems and in larger-scale, higher-throughput, high-duty applications, such as microbial fermentation and centrif…
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Sources of Bioburden You Might Have Missed
A problem with traditional mAb manufacturing is that there are so many potential entry points for microbial contamination. There are, however, ways to shut the door on contamination.
The risk …