Search results for "bioreactors"
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Single-Use Technologies Prove Effective for Viral Vector Process Development
The single-use systems most used, according to Chor Sing Tan, strategy manager at Cytiva, include T-flasks, roller bottles, cell factories or cell stacks, rocking bioreactors, fixed-bed culture system…
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Tools for Continuous Bioprocessing Development
• Bioreactors themselves, which control this large number of parameters, are large, complex to operate, and have not been standardized.
• Standardization is hampered by use of various platforms and…
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A Plastic Pipeline for Commercial Bioprocessing?
“Single-use bioreactors, currently available in sizes up to 2000–4000 L, are a potential solution when looking for smaller vessel capacities,” says Joe Prado, director, cGMP biomanufacturing operation…
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Improving Upstream Predictability
Used with high cell density cryopreservation, perfusion in N-1 and N-2 bioreactors can reduce the cost of goods by 13.5%, shortening run times and increasing production bioreactor titers, he says.
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Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
…offering the advantage of being scalable and readily industrializable using well known stirred tank bioreactors (STRs), as opposed to multi-tray culture systems. To reduce upfront expenses and to ove…
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What’s New in Upstream Technologies
Single-use sensor and adapter
Emerson’s Rosemount 550pH sensor and Rosemount 550DW dissolved oxygen (DO) sensor adapter provide improved sensor stability for single-use bioreactors and are suited …
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Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
Continuous processing techniques are another factor contributing to the popularity of smaller, single-use bioreactors. Although the industry as a whole has been slow to adopt these techniques, FDA act…
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The New World of Biopharmaceutical Manufacturing
Heintz (Solvay): The evolution of single-use containers from several decades ago to today’s gamma irradiation-stable bioreactors has been one of the most significant transformations; it was the impetu…
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Design Considerations for a Commercial Cell and Gene Therapy Facility
For mAb bioprocessing and viral-vector manufacturing, the equipment needed is similar, such as single-use bioreactors and standard harvest and downstream systems for clarification, tangential flow fil…
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Concentrating Feed—an Applicable Approach to Improve Antibody Production
Fed-batch studies in shake flasks and bioreactors. Fed-batch studies in shake flasks were carried out in 250-mL Erlenmeyer flasks in incubators at 36.5 oC with 5% CO2. Applikon 7-L benchtop bioreactor…