Search results for " method" in Articles / App Notes
Article
Improvements in Protein A Chromatography
What are your key take-aways after this study on the evolution of Protein A chromatography?
Many people talk about replacing protein A chromatography step with alternative purification methods d…
Article
Critical Quality Attributes Challenge Biologics Development
BioPharm International spoke with Tapan Das, head of stability, methods and analytical development at Bristol-Myers Squibb and Finance Committee member and past-chair of the BIOTEC Section at the Amer…
Article
Reconciling Sensor Communication Gaps
Where anchorage-dependent cells confound optical methods, permittivity easily quantifies them because the microcarriers are coulombically inert.cleaning validation, and calibration.
“You can also …
Article
Evaluating E&L Studies for Single-Use Systems
Analytical methods
In the three case studies, the following analytics were applied:
• Headspace sampling/gas chromatography/mass spectrometry (HS/GC/MS) and gas chromatography/mass…
Article
Increase Efficiency in Experimentation with Design of Experiments
Setting up an efficient study can help you save time and allow you to get the most out of screening and optimization experiments during method development. Also, good planning and relevant experimen…
Article
Biopharma in 2016: Higher Quality Drugs, Less Expensive Manufacturing
…l-molecule drug when FDA approved, for the first time, a manufacturer’s change in their production method from “batch” to continuous manufacturing. This new approval was for manufacturing Janssen Pro…
Article
How to Optimize Protein Desalting
But how do you determine which method to use? And how do you choose the right product for your needs? Learn more in this blog post about using size exclusion chromatography (SEC) for this purpose.
Article
Managing Risk in Raw Material Sourcing
To identify and assess risk, the company uses a documented risk-assessment process, facility audits, and a toolkit that includes such methods as failure modes and effect analysis, fishbone diagrams, a…
Article
Efficient Purification of the Pertussis Antigens Toxin, Filamentous Haemagglutinin, and Pertactin in Chromatography Workflows
The described method resulted in higher purity and yield than what can be expected from a purification process based on salt precipitations and sucrose gradient centrifugation.
Download applicatio…
Article
Improving Process-Scale Chromatography
In-line dilution (ILD) is one method. With ILD, floor space is reduced due to the use of buffer concentrates that are diluted with WFI-grade water as needed.
There are issues with this approach, h…