Search results for " scaling"
Article
Choose your Optimal Wavelength for Chromatography
ÄKTA™ chromatography systems and resins offer a wide range of solutions for isolating and purifying target molecules from research, through process development and manufacturing. With a variety…
Article
Download your Mechanistic Modeling eBook
What is mechanistic modeling in chromatography?
Mechanistic models use computer simulations to decrease the number of experiments needed during process development. The simulatio…
Article
Top Process Development Trends for 2022 and a Look into 2023
FDA approved 37 drugs in 2022, within the normal range for the past decade or so. The European Medicines Agency (EMA) was even more successful—approving a record 55 therapies. More than half of thes…
Article
Introduction to mRNA Manufacturing
Explore the mRNA universe with Cytiva. In this series, our scientists share their journey and insights on mRNA synthesis for research purposes. And they share their advice on how to sca…
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New hydrophobic interaction chromatography (HIC) handbook
Hydrophobic interaction chromatography (HIC) separates biomolecules under mild conditions according to differences in molecular hydrophobicity. HIC is often used as a next step to purify prote…
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Assessing leachables risk over a complete single-use, mAb process
Single-use systems (SUS) in biopharmaceutical manufacturing give advantages such as improved flexibility and plant efficiency, but also raise concern for compounds leaching from the pol…
Multimedia
Q&A: Oligonucleotide synthesis in process development and scale-up
In this video, Greg Farlow, RNA/DNA synthesis product specialist at Cytiva, talks about the typical challenges with oligonucleotide synthesis in process development and key considerations when scaling…
Article
Q&A: Oligonucleotide synthesis in process development and scale-up
Farlow
In this video, Greg Farlow, RNA/DNA synthesis product specialist at Cytiva, talks about the typical challenges with oligonucleotide synthesis in process development and key cons…
Article
Top Process Development Trends for 2021 and a Look into 2022
However, the focus in 2021 shifted beyond the pandemic to optimization and scaling up adeno-associated virus (AAV) production, process workflows and considerations for messenger RNA (mRNA) therapeutic…
Article
The Role of CDMOs in Cell and Gene Therapy Process Development
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An experienced contract development and manufacturing organization (CDMO) can ease scaling and tech transfer.