Search results for " scaling"
Article
Scaling a mAb production process to Xcellerex bioreactors
Moving a monoclonal antibody production process from a microscale bioreactor to the Xcellerex XDR single-use platform.
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Article
A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAbs at Large Scale
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We have developed a reliable small-scale model for a monoclonal antibody (mAb) perfusion process using TPP® TubeSpin® Bioreactor tubes and the ReadyToProcess WAVE 25 R…
Article
Scaling a mAb Production Process to Xcellerex Bioreactors
This article discusses moving a monoclonal antibody (mAb) production process from a microscale bioreactor to the Xcellerex XDR single-use platform.
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Article
Being Thorough When Transferring Technology
The challenges of scale up and tech transfer of biologics
BioPharm: What are the challenges when scaling up from lab scale to commercial scale in biologics?
Moscariello and Young (CMC Biologic…
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Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
The development of breakthrough FBRs bring new opportunities in readily developing and scaling adherent platforms as an alternative to STRs. FBRs provide a support matrix for cell adherence while allo…
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Single-Use Technologies Prove Effective for Viral Vector Process Development
…rs, while fixed-bed culture systems and stirred-tank bioreactors are the predominantly leveraged for scaling adherent and suspension processes, respectively,” Tan says. Use of microcarriers that supp…
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Mapping a Route for Cell and Gene Therapy Process Development
cell therapy applications), the focus of scaling of the manufacturing process may be different.
Scale up and mass production of the final product starting from a small seed bank (for instance, …
Article
Tools for Continuous Bioprocessing Development
The physical and chemical environment of the cells can strongly affect the cells’ physiology and productivity and, hence, must remain constant or above critical values during scaling.
First, the ga…
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Advances in Sterilization Technologies for Overcoming Viral-Vector Manufacturing Challenges
As a final note on scaling viral-vector sterile filtration processes, Laux points out that at CSL, it has been observed that not the volume, but the number of virus particles per filter area is the cr…
Article
Using Digital Twins to Model Process Chromatography
Mechanistic models provide process understanding for developing robust manufacturing processes and for scale up and tech transfer.
By Jennifer Markarian
A digital twin is a model of a proces…