Search results for " immunoglobulin"
Article
A Closer Look at Affinity Ligands
The most common example in the realm of bioprocessing is Protein A, which has an extremely high affinity for some immunoglobulin molecules. Other examples include antibody/antigen, enzyme/substrate, a…
Article
Enhancing Resins Addresses Purification Concerns
“Because traditional monoclonal immunoglobulin G (IgG) products share a similar structural and chemical motif, a platform purification approach can be utilized in the development and production of thi…
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Leveraging Computational Models of Glycosylation for Biopharma QA
• High levels of α-2,6 sialylation have been linked with enhanced anti-inflammatory activity in intravenous immunoglobulin (IVIg) therapies (15) and would, thus, be a desirable attribute of immune-mod…
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A Look at the Affinity Chromatography Landscape
Libraries of ligand peptides have been used for the purification of fibrinogen and immunoglobulins. Other libraries consist of polypetides produced by means of phage display and/or ribosome display an…
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3rd BioProcessing Asia Preview: Q&A with John Curling
The 3rd BioProcessing Asia conference will take place November 12-15, 2018 on Langkawi, Malaysia. This week, Bioprocess Development Forum talks with John Curling, Conference Chair, about the upcomin…
Article
Process Chromatography: Continuous Optimization
“This resin chemistry is beneficial for the separation of large molecules, such as viruses, vaccines, and immunoglobulin M,” says Westman.
Biosimilars and other challenges
The increased trend towa…
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N-Glycan Analysis of Biotherapeutic Proteins
This article summarizes the approaches, challenges, and future perspectives for the characterization of N-glycans in biopharmaceutical products.
By Aled Jones
Protein glycosylation, the addi…
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mAbs to Watch in 2016
Other competitors to dupilumab will likely include AstraZeneca’s Xolair (omalizumab), which was approved in the US in 2003 and works by another mechanism as well (by binding to the Ce3 domain of immun…
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Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
There are two main categories of bispecifics, immunoglobulin G (IgG)-like bispecific antibodies, and small bispecifics. IgG-like bispecifics have a conserved immunoglobulin-constant domain that demons…
Article
Ensuring the Quality of Biologicals
began elaborating monographs on biologicals as an early priority with the first biological monographs on vaccines for human use, immunosera, and immunoglobulins appearing in Volume 2 of the first edit…