Search results for "downstream"
Article
Future Downstream Process Development Solutions for Advanced Therapies
downstream
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Peter Guterstam, PhD, Product Manager of Next Generation Resins & Technologies at Cytiva, provides insight into solutions for ad…
Article
Can You Trust a Machine for Downstream Bioprocess Buffer Preparation?
…ity against limited footprint expansion alternatives?
- Can you trust a machine for downstream bioprocess buffer preparation?
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Article
Developing an Efficient Adenovirus Downstream Purification Process
This application note describes the development of downstream chromatography steps for purification of adenovirus from HEK293 cell culture harvest.
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Article
Full Single-Use Downstream Process? Not Any Time Soon.
But where we see full single-use upstream processes, downstream is often a hybrid solution. Here’s why SUTs will not completely replace reuse systems in the near future.
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Article
Bioburden Entry Points in Downstream Processing
If you work in bioprocessing, you are no doubt aware of the need to prevent bioburden entry and proliferation, and reduce the complexity of the equipment and processes involved. Anastasia Lolas, for…
Poster
Fast Trak Services: a collaborative project to accelerate downstream biosimilar process development
This case study demonstrates the optimization of the downstream purification process to improve product purity and recovery of the biosimilar Fc-fusion protein. The optimization work was conducted by…
Article
Digitalized PD: Speeding up downstream process development
Mechanistic models enable the simulation of chromatography processes based on fundamental natural laws, such as fluid dynamics and thermodynamics. In silico simulations of chromatography proce…
Article
Improving Lentiviral Vector Downstream Processing Workflows
However, these downstream workflows are long, require substantial manual labor, and suffer from low yields of infectious virus. This article discusses process development pain points of a modern workf…
Article
Current Innovations and Practices To Address Microbial Contamination in Downstream Bioprocessing
Bioburden control is an area of serious concern for anyone making mAbs or other biologicals. Manufacturers’ efforts to avoid microbial contamination are today being complemented by development…
Article
SEC in the Modern Downstream Purification Process
Kevin O'Donnell, “SEC in the Modern Downstream Purification Process,” BioPharm International 28 (3) 2015.