Search results for " process" in Articles / App Notes
Article
Chromatography Process Development Going Smarter
Especially, he explains how methods such as raw material insights and mechanistic modeling enable accelerated process development and improve general process understanding, robustness, and performance…
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Accelerating VLP purification process development
Indeed, a method for the large-scale production of VLPs is production in suspension cell culture, and extracting the VLPs from the cell culture supernatant is a time and labor-intensive process.
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Managing Residual Impurities During Downstream Processing
Host-cell DNA will also be present and must be minimized by the purification process. Elemental impurities can be present as well. There is, however, no set of standard assays for the determination of…
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Mechanistic Modeling: Does it Have a Future in Process Development?
Novo Nordisk uses mechanistic models for the development of selected downstream process steps. Following his keynote presentation to attendees at the recent HTPD Conference in Italy, Arne Staby, PhD, …
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Paring Down Impurities in Downstream Processing
Each decision directly influences what final options will be available on arriving at the final stages of downstream processing and then interlock with fill/finish steps, which demand still more evalu…
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Improving Productivity During Process Development and Scaling of Your Process
Topics covered include:
0:54 - Overview of the process development workflow and important areas of focus
3:32 - Major goals for moving from small scale culture to larger processes and challeng…
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Common Challenges in Cross-Functional Process Development
James is a leading industry consultant with broad chemistry, manufacturing, and controls experience in product development and quality that encompasses early process development to commercial operatio…
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Integrated Semi-Continuous Process for mAb Production
Linking these different steps together to a fully continuous process can be a challenging task, and studies in the area of continuous processes typically deals with single unit operations, such as per…
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Process Economic Simulation for Scalable Production of Adenovirus
The novel process was compared with a reference process in both stainless-steel and single-use configurations across various production scales and scenarios. The process, based on modern tools and tec…
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Process development using a nonaffinity method vs Cytiva™ Protein Select™ resin
We compared the complexity and time spent in developing the process. Developing the full process was two times faster when Cytiva Protein Select resin was used in the first step.
We also studied s…