Search results for " resin" in Articles / App Notes
Article
Five Control Strategy Options to Prevent Resin Variability Impact
Here are the pros and cons of five control strategies that can provide process consistency even in the presence of chromatography resin variability.
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Article
Risk Assessment: Studying Chromatography Resin Variability
This article focuses on process robustness and the impact of chromatography resin attributes as well as how to identify which parameters and interactions to focus on in your process characterization s…
Article
Sephadex™ Size Exclusion Resin Turns 60
Do you know the story behind Sephadex, which enabled today's large-scale production of biopharmaceuticals? An inadvertent discovery in 1959 became the foundation for today's biopharma industry. This i…
Article
New Selection Guide: Ion Exchange Chromatography Columns and Resins
Use these decision trees to find the most appropriate resin for your needs.
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Article
Interpreting Protein Binding Capacities for Chromatography Resins
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Comparing the protein-binding capacities of resins from different suppliers is not straightforward because different methods may have been used and these methods are n…
Article
Sanitization of AxiChrom™ Columns Packed with Chromatography Resin
This study evaluates sanitization methods based on 1 M sodium hydroxide (NaOH) as sanitization agent using methodology previously developed for peracetic acid (PAA).
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Article
Process Chromatography: Continuous Optimization
A combination of chromatography steps using different resin chemistries is used to purify the biologic drug substance to an acceptable level. The number and types of chromatography steps depend on the…
Article
A Look at the Affinity Chromatography Landscape
…f process-related impurities such as host-cell proteins and DNA, with Protein A the most widely used resin. Resin suppliers have in recent years been challenged to increase the productivity of the ca…
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Implementation of Raw Material Control Strategies in the Manufacture of Single-Use Bioprocessing Containers
The authors were able to show that a single resin can be converted to films that lead to substantially different amounts of leached degradation products, depending on how the resin is processed.
T…
Article
Improving Process-Scale Chromatography
The development of new resin chemistries including enhancements to Protein A for monoclonal antibody (mAb) capture, increasing use of automation, implementation of single-use technologies, and explora…