Search results for " scale-up"
Article
Process Development: 2020 Reflections and 2021 Possibilities
Scaling up viral vector and virus manufacturing processes prompts the need for discussion on general guidelines for how to go about the scale-up process, which was of particular interest to Bioprocess…
Article
Akron Bio Will Install a Cytiva FlexFactory to Manufacture Plasmid DNA
Materials for cell and gene therapy manufacturing, such as pDNA, have been experiencing capacity constraints, and the platform will enable rapid scale-up to address supply chain bottlenecks.
“With…
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Testa Challenge 2020 Attracts Leading International Bioprocessing Innovators
Held over an intensive week in the Testa Center located at Cytiva´s Uppsala site, a unique biomanufacturing scale-up facility, the Testa Challenge aims to allow start-ups, research groups and companie…
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Biomanufacturing: Demand for Continuous Bioprocessing Increasing
… - Need for greater process control
- Cell line stability problems
- Ability to scale-up process.
Interestingly, while approximately 76% believe downstream continuous b…
Article
Cytiva Expands Offering for ReadyToProcess™ Columns
ReadyToProcess columns are offered in seven inner diameters to meet the needs of upstream production. You can enjoy the flexibility of using our prepacked ReadyToProcess columns from benchtop to ful…
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Flexible Facilities for Viral Vector Manufacturing
When larger batches are needed, either scale-up or scale-out is used, depending on the type of process. Makowiecki explains that vector production using adherent cells in fixed-bed bioreactors is limi…
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Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
With a scale-out rather than scale-up approach to meeting production requirements, there is a greater risk of variability in process conditions and product quality between individual bioreactors. Bior…
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Mapping a Route for Cell and Gene Therapy Process Development
While cell and gene therapies differ in many ways, some of the best practices for process development and validation are similar.
By Cynthia A. Challener
…
Article
Cytiva to Expand KUBio Through Close Collaboration with Pharmadule Morimatsu
Cytiva has announced it will be working closely with Pharmadule Morimatsu to expand its KUBio “factory in a box” so that biopharma manufacturers will be able to quickly scale up vaccines, viral vect…
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Best Practices for Selecting a Top-Quality Cell Line
Similarly, production cell lines must be well characterized so that scale-up from shake flasks to large bioreactors does not require extensive optimization.
“Equally important,” stresses Fisch,…