Search results for "filtration" in Articles / App Notes
Article
A Plastic Pipeline for Commercial Bioprocessing?
More than 75% use filled media bags, preassembled tubing sets, depth filters, bioreactors, sampling systems, and tangential flow filtration devices. Less than two-thirds use disposable chromatography …
Article
Integrated Semi-Continuous Process for mAb Production
In brief, the mAb process consists of perfusion cell culture, continuous capture chromatography, viral inactivation (VI), post VI filtration, batch polishing chromatography, and a final pH adjustment …
Article
The Challenge of Disruptive Technologies in Bioprocessing
A salt-tolerant resin can be beneficial to a purification process by decreasing the need for dilution or eliminating tangential flow filtration steps all together. In addition, there has been increase…
Article
Bioburden Control in the Biopharmaceutical Industry
Field, “Bioburden Control at the Sterile Filtration Step: A Risk-Based Approach,” presentation to European Biopharmaceutical Enterprises (May 2013).
10. Critical Process Filtration Inc., “Partic…
Article
The New World of Biopharmaceutical Manufacturing
Single-use sensors have been developed for a variety of process parameters for downstream steps such as chromatography, tangential flow filtration, direct filtration, and fill/finish, as well as for s…
Article
Unifying Continuous Biomanufacturing Operations
In terms of cell retention devices, alternating tangential filtration (ATF) allowed a significant technological step ahead compared with tangential-flow filtration (TFF), comments Morbidelli, although…
Article
Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
Disposable, single-use filtration is an alternative to outdated centrifugation methods that are difficult to scale and complicated to use. Expanded-bed absorption (EBA) offers an alternative to oversi…
Article
Ensuring the Biological Integrity of Raw Materials
(1)
Standard procedures for inactivation of adventitious agents include the use of heat, filtration, pH, and gamma irradiation. Thorough cleaning of equipment, testing, and review of material sour…
Article
Selection Guide Size Exclusion Chromatography Columns and Media
Size exclusion chromatography (SEC), also called Gel filtration (GF), separates molecules on the basis of differences in size as they pass through a SEC medium packed in a column. A variety of media…
Article
Going Small to Achieve Success on the Commercial Scale
Scale-down models are used in the development of nearly every unit operation in the overall biopharmaceutical manufacturing process, including both upstream and downstream steps, and separation and fi…