Search results for "filtration" in Articles / App Notes
Article
New Therapies Present Scaling Challenges
New Therapies Present Scaling Challenges
Manufacturing differences between traditional mAb therapies and newer biotherapeutics dictate whether processes should be scaled up, scaled out, or use an al…
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Addressing the Complex Nature of Downstream Processing with QbD
When platform data already exist, others may require less study, such as affinity chromatography steps, low-pH viral inactivation, and nanofiltration, says MacDonald. “There can always be a need to st…
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Sephadex™ Size Exclusion Resin Turns 60
Do you know the story behind Sephadex, which enabled today's large-scale production of biopharmaceuticals? An inadvertent discovery in 1959 became the foundation for today's biopharma industry. This i…
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Analytical SEC: How Does Back Pressure Relate to Resolution?
High resolution in HPLC is not achieved by applying back pressure to the column. Let’s straighten out what really helps you achieve high-resolution analytical SEC data.
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Protein Analysis with Size Exclusion Chromatography
Size exclusion chromatography (SEC) is widely used in several different analytical applications from basic research to quality control of biotherapeutics. This white paper presents fundamentals abou…
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Achieving Process Balance with Perfusion Bioreactors
Alternating tangential flow (ATF) filtration technology (developed by Refine Technology, now Repligen) is commonly used.
For perfusion processes used to manufacture chimeric antigen receptor (CAR)…
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Scalable Viral Vector Manufacturing
For example, single-use bioreactors, filtration, and chromatography techniques are suitable for virus production.
Due to the diversity of viruses, platform solutions are challenging to implement e…
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Scaling Up Novel Therapies
Scaling Up Novel Therapies
Platform processes have improved monoclonal antibody scale-up. Can they do the same for personalized therapies?
By Agnes S…
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State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
• The downstream areas seen as needing the most improvements are now single-use purification, continuous downstream purification, and virus filtration. Again, desires for single-use technology took th…
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Putting Viral Clearance Capabilities to the Test
“Virus retentive filtration is based on size exclusion, and a model of a specific size will represent all viruses of the same or greater size. But removal with chromatography steps is based on the vir…