Search results for " conjugate"
Article
Process Development: What May Lie Ahead in 2018?
Such next-gen antibodies include antibody drug conjugates, engineered antibodies, bispecific antibodies, antibody fragments, antibody-like proteins and biosimilar antibody therapies.
The productio…
Article
Process Chromatography: Continuous Optimization
In cases where the molecule is highly hydrophobic or contains a very hydrophobic conjugate, it can be difficult to elute even in low salt conditions. “Recently developed HIC resins from Thermo Fisher …
Article
Generating a Fully Processed Antibody
The authors outline cell-line development and process scale-up for an antibody program in which the antibody requires additional processing by a site-specific enzyme for correct functionality.
B…
Article
A Q&A With Prof. Alois Jungbauer: The Role of HIC in Biotech
I am also convinced that HIC will be a useful tool for purification of some of the new types of biomolecules, such as antibody drug conjugates (ADC). I am aware that HIC is being considered complex. F…
Article
USP Publishes Monoclonal Antibody Guidelines
When the active substance is a conjugated antibody, such tests can be performed on the purified intact antibody before modification or conjugation.
The proposed new general chapter does not apply t…
Article
Challenges in Analytical Method Development and Validation
While the biopharmaceutical industry has had success in reducing risk by incorporating analytical platform technologies for monoclonal antibody products, new molecules and drug conjugates pose additio…
Article
Extractables in Single-Use Systems Used in ADC Manufacturing, Part 2
We performed extractables studies on single-use chromatography and tangential flow filtration systems using common solvents in ADC manufacturing, DMA and DMSO. The low levels of extractables f…
Article
A Closer Look at Affinity Ligands
Affinity ligands play an exciting role in the ever-growing sphere of downstream processing. In speaking with BioPharm International®, Phillip Elliott, PhD, associate director of Process Development,…
Article
Exploring the world of antibodies: mAbs, Fabs, dAbs, and bsAbs
There is a vast array of antibody variants, including multispecific (msAb), bispecific antibodies (bsAb), antibody fragments (Fab, dAb, scFv), and antibody-drug conjugates (ADC). But with this…
Article
Fundamentals of hydrophobic interaction chromatography
…nt proteins and peptides
* monoclonal antibodies (mAbs), bispecific mAbs and antibody-drug conjugates (ADC)
* mRNA
* plasmid
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