Search results for " adcs"
Article
ADC Development Robust Despite Lackluster Performance
The target for ADCs has primarily been cancer, and the cytotoxic agents that are used in ADCs are typically more potent than currently used anti-cancer drugs (1).
The ADC construct combines a t…
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Tackling Analytical Method Development for ADCs
Fortunately, both improvements in analytical technology and increased experience with ADCs are leading to improved strategies for analytical method development and validation.
Both small and large…
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Extractables Studies for Single Use Systems Used in ADC Manufacturing, Part 1
Single‑use (SU) systems have great potential in antibody‑drug conjugates (ADC) manufacturing. The use of organic solvents in the ADC process might , however, raise questions about potential leac…
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Extractables in Single-Use Systems Used in ADC Manufacturing, Part 2
We performed extractables studies on single-use chromatography and tangential flow filtration systems using common solvents in ADC manufacturing, DMA and DMSO. The low levels of extractables f…
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Witnessing Major Growth in Next-Generation Antibodies
Many technologies
Next-generation antibody formats include ADCs, other bioconjugates, bispecific (multispecific) antibodies, nanobodies, engineered antibodies, antibody fragments, and antibody-lik…
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Being Thorough When Transferring Technology
A good example for ADCs involves a mix-and-match approach to the differences that exist between scales. There are many recent advances that have addressed these issues, such as single-use bioreactors …
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Nurturing Knowledge from Disparate Data Streams
Leveraging vast quantities of analytical data requires digitalization and platform integration.
By Cynthia A. Challener
jijomathai/stock.Adobe.comAnalytical instrument…
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The Challenge of Disruptive Technologies in Bioprocessing
In addition, there is a need for new resin chemistries for polishing end product because the bioprocessing of complex therapeutic molecules such as ADCs, antibody fragments, and bispecifics are result…
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Aseptic Processing: Keeping it Safe
To protect the worker making these specific types of ADCs, a more complex, negative pressure isolator is typically used, notes Newman. Gary Partington, technical sales and marketing manager of Walker …
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Addressing the Challenges in Downstream Processing Today and Tomorrow
To enable straightforward downstream processing of ADCs, two main strategies have been used to generate more homogeneous molecules. These are the incorporation of additional free cysteines that can th…