Search results for " fluid"
Article
Fluid Handling in Biopharma Facilities
By Susan Haigney
Contamination prevention in biopharmaceutical manufacturing is crucial, and the proper handling and storage of fluids is essential to limit the possibility of contamination. Facili…
Article
Understanding fluid dynamics within a chromatography column
See how fluid flow effects within a chromatography column are used by mechanistic models.
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Article
Best Practices in Qualification of Single-Use Systems
Because biomanufacturing may involve processing of fluids containing these chemical compounds, the chemical compatibility of single-use components with process fluids under process conditions should b…
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Tools for Continuous Bioprocessing Development
Such high cell densities can be demanding for gas transport and fluid addition. In addition, removal with cell retention is a challenge. In fact, operation in continuous perfusion culture mode has not…
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Modeling Bioreactor Performance
“Performance may be as much about the integration of the bioreactor in the overall biomanufacturing operation as it is about the physics of fluid dynamics. Analyzing with simulation scenarios, fluid p…
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Challenges in Cell Harvesting Prompt Enhancements
Centrifugation challenges
The centrifugation step uses the density difference between cells and the surrounding fluid, accelerating the separation and settling of cells. Industrial applications ty…
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Insider Recommendations for Getting Started with Mechanistic Modeling of Chromatography
So of course, fluid dynamics is crucial here—both the fluid dynamics within the chromatography system you are using and, of course, the column. We can counterize those with very simple pulse experimen…
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Using Digital Twins to Model Process Chromatography
With a mechanistic approach, relatively sparse experimental data are used to describe the full dynamics of the system at hand, using deceptively simple fundamental natural laws from the fields of flui…
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Introducing Supor Prime Filters: A Filtration Solution for High-Concentration Therapies
It is harder to process fluid through the filter and it clogs faster. Manufacturers are compensating for this with oversized filters that have more hold-up. In a highly concentrated drug, every drop c…
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Single-Use Technologies Prove Effective for Viral Vector Process Development
These single-use solutions, according to Ram, have alleviated the operational challenges for adherent processes at the terminal reactor stage, but are known to have issues with even distribution of fl…