Search results for "ADCs"
Article
ADC Development Robust Despite Lackluster Performance
The target for ADCs has primarily been cancer, and the cytotoxic agents that are used in ADCs are typically more potent than currently used anti-cancer drugs (1).
The ADC construct combines a t…
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Tackling Analytical Method Development for ADCs
Fortunately, both improvements in analytical technology and increased experience with ADCs are leading to improved strategies for analytical method development and validation.
Both small and large…
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Extractables Studies for Single Use Systems Used in ADC Manufacturing, Part 1
Single‑use (SU) systems have great potential in antibody‑drug conjugates (ADC) manufacturing. The use of organic solvents in the ADC process might , however, raise questions about potential leac…
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Extractables in Single-Use Systems Used in ADC Manufacturing, Part 2
We performed extractables studies on single-use chromatography and tangential flow filtration systems using common solvents in ADC manufacturing, DMA and DMSO. The low levels of extractables f…
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Witnessing Major Growth in Next-Generation Antibodies
The global market for next-generation antibodies, including antibody drug conjugates (ADCs), engineered antibodies, bispecific antibodies, antibody fragments, antibody-like proteins and biosimilar ant…
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Being Thorough When Transferring Technology
BioPharm: Are there specific challenges for the tech transfer of antibody-drug conjugates (ADCs)? Monoclonal antibodies? Cell therapies?
Moscariello and Young (CMC Biologics): The major challenges…
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Nurturing Knowledge from Disparate Data Streams
Anderson points to antibody-drug conjugates (ADCs) as an example. “ADCs comprise an antibody, a small-molecule cytotoxic payload, and a linker of some kind, which can be an oligomer or other small to …
Article
The Challenge of Disruptive Technologies in Bioprocessing
The industry pipeline is growing in complexity to include emerging molecules such as bispecific antibodies, antibodydrug conjugates (ADCs), and those viral vectors for gene and cell therapies. Some of…
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Aseptic Processing: Keeping it Safe
Concerns related to operator safety exist when dealing with highly potent or cytotoxic drugs, such as is the case with the manufacture of antibody drug conjugates (ADCs) with cytotoxic payloads. To pr…
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Addressing the Challenges in Downstream Processing Today and Tomorrow
ANTIBODY-DRUG CONJUGATES
Numerous antibody drug conjugates (ADCs) are in clinical trials with most of them being used in cancer treatment with a toxin payload (26). The major downstream challenge …