The diversity of antibody variants in today’s pipeline presents unique challenges for purification. Purification platforms used for many monoclonal antibodies (mAbs) need to be adopted for antibody variants to simplify protocols and improve purity and yield. The safety and efficiency requirement of conventional mAb processes are key also for antibody variants. Here we present strategies for purifying bispecific antibodies and antibody fragments having the molecule type and the impurity profile in mind.