Search results for " purification"
Article
Platform Technologies Improve Protein Expression
…asmid design, cultivation medium, growth conditions, equipment, scalability, stability, and matching purification capability, to name but a few. Primary drivers to the development of a new therapeuti…
Poster
Evaluation of Protein A resin lifetime during extensive use (overloading) in continuous chromatography mode
In recent years, continuous chromatography has emerged as an alternative to batch operations to improve productivity or increase resin capacity utilization of chromatography purification processes. …
Article
Witnessing Major Growth in Next-Generation Antibodies
The synthesis of these molecules can be complex and involve extensive purification to obtain the desired structure.
“The further removed these molecules are from conventional antibody structures, …
Article
Critical Quality Attributes Challenge Biologics Development
BioPharm: How are CQAs in biologics defined?
Das (BMS): For recombinantly produced biologics, special attention is paid to the cell culture and purification process parameters as well as storage c…
Article
Downstream Processing for Cell-Based Therapies
By Qasim A. Rafiq, Fernanda Masri
With increasing numbers of advanced therapies—including cell and gene therapies—entering early- and late-stage clinical development, significant focus has been …
Article
HTPD: Optimizing a mAb Chromatography Polishing Step
Development of robust purification processes requires significant time and resources. In addition, steadily increasing demands from regulatory authorities for better understanding and control of man…
Article
Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
Downstream processing goals include multiple stages of purification and concentration. Disposable, single-use filtration is an alternative to outdated centrifugation methods that are difficult to scal…
Article
Ensuring the Biological Integrity of Raw Materials
“If there is a contamination, you catch it early—before you send the batch for purification.”
Trending strategies for testing raw materials are included in GMP practices, quality by design, and pr…
Article
Increase Efficiency in Experimentation with Design of Experiments
Setting up an efficient study can help you save time and allow you to get the most out of screening and optimization experiments during method development. Also, good planning and relevant experimen…
Article
Biopharma in 2016: Higher Quality Drugs, Less Expensive Manufacturing
…ne Development
Overcoming Buffer Challenges With In-Line Conditioning
A Platform Approach to Purification of Antibody Fragments
References
1. Walker, Nigel, Innovation at the Heart of…