Search results for " purification"
Article
Advancing Single-Use Technology Through Collaboration
…hat uses fully single-use technology is the bioreactor, which is far upstream: there are significant purification processes in place further downstream. According to Duncan Low, scientific executive …
Article
Mixing dynamics in a large volume single use mixer
Upstream applications such as medium preparation and harvest require fast and efficient mixing whereas downstream mixing operations used in purification and separation processes require sensitive mi…
Article
Technology solutions simplifying chromatography unit operations
This application note describes how modern tools and technology solutions can help facilitate chromatography operations for an effective and productive protein purification process.
Download the a…
Article
Affinity Chromatography Handbook in 3 Volumes
Affinity chromatography (AC) separates proteins on the basis of a reversible interaction between a protein (or group of proteins) and a specific ligand coupled to a chromatography matrix. The techni…
Article
Analysis of Glycosylation in Biosimilars
Monosaccharide analysis can also give a purity check: high levels of glucose might suggest the breakdown of Sephadex beads, for example, in the purification process, and high mannose levels may indica…
Article
Vocabulary of the chromatographer
Similar to other technical areas, chromatographers generate their own vocabulary, all with a good scientific purpose and for a common understanding. However, the same terminology can be used in othe…
Article
Maximize resin usage with continuous bioprocessing
The technology employs three or more chromatography columns to create a continuous purification step. In a PCC setup, columns are switched between the loading and nonloading steps, such as wash and el…
Article
Managing Biomanufacturing Capacity Expectations
BioPlan found that the development of more efficient single-use products, better downstream purification technologies, the introduction of continuous downstream operations, and increased modularizatio…
Article
Fast Turnaround with Automated Column Packing
Packing success is, therefore, key to ensure an efficient purification process with high yield and throughput.
Packing success from the start
Today it is possible to get packing right on the f…
Poster
Integration of continuous upstream and downstream operations in mAb production
We describe the integration of a high-performing upstream cell culture process with downstream purification utilizing emerging technologies such as periodic counter-current (PCC) chromatography and st…