Search results for " purification"
Article
Your Reliable Downstream Bioprocessing. Our Proven AxiChrom Columns
The goal for biopharmaceutical manufacturers is to develop a process that will deliver material for clinical trials quickly and smoothly, achieve success in these trials, and scale up to commercial …
Article
Lessons Learned Accelerate Vaccine Development
High-throughput and single-use technologies are also being leveraged to accelerate key aspects of manufacturing processes, such as determination of appropriate media, resins for purification, formulat…
Poster
Modes of controlling charge variant distribution in Mab production
The characteristics of a biological drug, for example, charge variant profile, are determined to a large extent by the upstream expression system and conditions, but can also be influenced by the pu…
Article
Going Small to Achieve Success on the Commercial Scale
Meizinger, a process engineer in Genzyme’s Purification, Manufacturing Science, and Technology Laboratory.
Scale-down models are used in the development of nearly every unit operation in the overa…
Article
Biopharma in 2015: A Year for Approvals and Innovations
Insiders agree that 2015 was a banner year for biopharma. Last year’s new drug approvals reached 51, besting every year since 1950. Twenty approvals (39%) went to biological drugs—up from 35% in 201…
Article
Implications of Cell Culture Conditions on Protein Glycosylation
Production is fast using simple media; however, purification can be challenging. Rapid production of proteins with primitive glycosylation can be achieved using yeast. Insect cells, generally used wit…
Poster
Continuous chromatography in downstream processing of a monoclonal antibody
In this study, periodic counter current (PCC) chromatography and straight-through processing (STP) technologies were evaluated in a continuous three-step monclonal antibody (MAb) purification proces…
Article
Capto™ Core 700 in Vaccine Processing
The aim with this white paper is to discuss the advantages of using Capto Core 700 in virus purification compared to size exclusion chromatography (SEC), a technique commonly used in several vaccine…
Article
Best Practices in Qualification of Single-Use Systems
Culter, Protein Purification Protocols, Second Edition (Humana Press, 2004).
14. F. Jameel and S. Hershenson, Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals (W…
Article
Fluid Handling in Biopharma Facilities
For example, as the productivity of upstream processes has improved, the need to run a greater number of cycles through purification equipment has also increased, which increases buffer consumption. A…