Search results for " purification" in Articles / App Notes
Article
Updating Viral Clearance for New Biologic Modalities
For traditional downstream processing templates, such as monoclonal antibody (mAb) purification, the technologies used to ensure virus removal are well established and their effectiveness has been con…
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Eliminating Residual Impurities Starts with a Strategic Plan
…ce that may include a limit specification in a release test or validating the removal during product purification. Others are more complex to define, such as those that originate from the cellular sy…
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Cytiva Opens Biotechnology Manufacturing Center in UK
In the first half of 2019, the center will start producing a fiber-based chromatography purification platform, which has the potential to improve efficiency in the purification steps of manufacturing …
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Scalable Viral Vector Manufacturing
Is virus purification also challenging? Are platform solutions a realistic approach?
Yes, the purification process can be quite complex. Viruses are much larger than recombinant proteins and ant…
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Making the Move to Continuous Chromatography
“Multicolumn chromatography has long been an accepted continuous purification practice by small-molecule manufacturers, but is just now gaining traction in the biomanufacturing space,” he says.
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Unifying Continuous Biomanufacturing Operations
Downstream continuous purification has seen some success as well, mostly through the integration of various chromatography column sequences. But the continuous production of biologics in a closed, tot…
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Reconciling Sensor Communication Gaps
The desirability of platform purification, best exemplified in monoclonal antibody (mAb) downstream processing, simultaneously creates and reduces the need for extensive downstream monitoring. Platfor…
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Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
The final yield here is determined by the product titer of the production bioreactor, combined with the efficiency of the downstream purification steps, both of which will be driven by the details of …
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Continuous Manufacturing: A Changing Processing Paradigm
Employing straight-through processing in mAb purification could significantly improve throughput with a much smaller manufacturing footprint, presenters of the aforementioned webinar conclude. Case st…
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QbD and PAT in Upstream and Downstream Processing
While scale-down models combined with screening and design space DOEs can be used to understand cell expansion and the cell-production bioreactor processes, full purification can be time consuming and…