Search results for " purification" in Articles / App Notes
Article
New hydrophobic interaction chromatography (HIC) handbook
The role of this technique in protein purification in the lab and at bioprocess scale, the principle of the technique, and the equipment and resins needed are described in this detailed handbook.
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Optimization of an antibody polishing step
But what if DoE fails to find robust process conditions? This article shows how to achieve higher yields using mechanistic models to optimize an antibody purification process.
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Single-Use Technologies Prove Effective for Viral Vector Process Development
Challener
Upstream viral-vector processes can have significant impacts on downstream purification requirements. The presence of serum, culture harvest viability, turbidity, cell lysis r…
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Future Downstream Process Development Solutions for Advanced Therapies
downstream
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Peter Guterstam, PhD, Product Manager of Next Generation Resins & Technologies at Cytiva, provides insight into solutions for ad…
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Guide to Polishing Chromatography in Process Development
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This article shares the factors you should consider when developing your polishing steps—from the basics to the typical challenges faced, and how to overcome them.
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Understanding Protein Production from Start to Finish
Most scientists working with exploring proteins and developing specific target biomolecules use several steps including cell culture, sample preparation, purification, and analysis. This requires unde…
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What If You Could Remove Your Antibody Aggregates Already in the Protein A Step?
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In this study, the potential of Protein A chromatography to separate antibody monomer from HMW species was investigated. A design of experiments approach…
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Process Development: 2020 Reflections and 2021 Possibilities
Speaking of game changers, Fibro chromatography, a recently launched chromatography platform, has been shown to enable purification cycles in minutes instead of hours. This results in higher throughpu…
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Connected, Automated Downstream Process for mAb Screening and Evaluation
This study was done to show both proof of principle for an automation solution for a lab-scale protein purification set-up, and that it would significantly decrease hands-on time, while assuring that …
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Improving Upstream Predictability
Some of the latest biopharmaceutical manufacturing facility designs have cell culture and some purification unit operations take place in one location, notes Mohindra.
At the same time, the …