Search results for " monoclonal" in Articles / App Notes
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Integrated Semi-Continuous Process for mAb Production
A complete process for the production of a biopharmaceutical consists of a great number of distinct unit operations, for example, cell culture, filtration, and chromatography. Linking these differen…
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Challenges in Cell Harvesting Prompt Enhancements
The higher titers and cell densities made the initial clarification of monoclonal antibody (mAb) product more difficult, driving the need for filtration technologies that can handle the large amounts …
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Automation Trend in Fill/Finish Reduces Contamination Risk
The company installed the new filling line to meet demand for innovative biologics, including vaccines, gene therapies, oncolytic live virus-based therapies, monoclonal antibodies, and recombinant pro…
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Capacity and Performance of a Next Generation Protein A Chromatography Resin
This application note demonstrates the binding capacity and purification performance of MabSelect PrismA in comparison with its predecessor products for both polyclonal and monoclonal antibodies. An i…
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Process Development: What May Lie Ahead in 2018?
Aligning with this news, Process Development Forum readers showed strong interest in an article discussing next-generation antibodies, which are often more potent and more specific than traditional mo…
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Development of Purification for Challenging Fc-Fusion Proteins
In response, titers for monoclonal antibodies (mAbs) and Fc-fusion proteins have significantly increased (1-5).
Particularly for Fc-fusion proteins, these improvements have resulted in a …
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Patenting Prospects for Cell-Based Therapies
For example, in the Federal Circuit decision, In re Alonso (11), the claimed invention was directed to antibody reagents and methods for treating neurofibrosarcomas using a monoclonal antibody idiotyp…
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N-Glycan Analysis of Biotherapeutic Proteins
More than half of all biotherapeutics are glycosylated (2), including monoclonal antibodies (mAbs), Fc-fusion proteins, clotting factors, and cytokines such as erythropoietin. Of these, mAbs represent…
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Single-use Bioreactors Have Reached the Big Time
“[Cytiva] is taking its experience in single-use bioreactor technologies for monoclonal antibody, recombinant protein, and vaccine processes and applying it in our Xuri line of cell therapy equipment …
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Improving Process-Scale Chromatography
The development of new resin chemistries including enhancements to Protein A for monoclonal antibody (mAb) capture, increasing use of automation, implementation of single-use technologies, and explora…