Search results for " production"
Article
Challenges of scaling up buffer production for GMP and how to evaluate different solutions
You will learn at what scale does it make sense to outsource your buffer production or invest in a hardware solution such as inline dilution or inline conditioning.
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Article
Recombinant Adeno-Associated Virus Type 5 Production Process
A scalable recombinant adeno-associated virus (rAAV) type 5 production process was developed using transfected HEK293 suspension cells.
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Webcast
The GMP of AAV: Purification for Clinical Production
And we’ll discuss ways to overcome the key challenges in bringing these processes to clinical production. Last, we’ll explore what’s on the horizon for systems and other purification techniques design…
Article
Tips for Viral Vector Production
The viral vector market is highly active, and the interest in production technologies is driven by recent approvals in cell and gene therapy. In this blog article, insights are shared around the cha…
Poster
A Scalable Adenovirus Production Process, from Cell Culture to Purified Bulk
In this study, we have combined technical evaluation of process steps and process economy calculations, from AdV production in cell culture to purified bulk product in up to 10 L scale. Human AdV5, ex…
Resource
Plasma Product Biotechnology Conference
The Plasma Product Biotechnology Conference Series, now in its 12th year, will provide a topical and stimulating program detailing the latest developments of importance to the industry. The sessions…
Article
Process Economic Simulation for Scalable Production of Adenovirus
The novel process was compared with a reference process in both stainless-steel and single-use configurations across various production scales and scenarios. The process, based on modern tools and tec…
Article
Achieving Efficient Adenovirus Upstream Production
This application note describes the production of adenovirus in HEK293 suspension cells in a bioreactor system. Triplicate cultures demonstrate a reproducible and robust batch production of adenovirus…
Poster
Repurposing Fed-Batch Media and Feeds for Highly Productive CHO Cell Perfusion Processes
The authors developed a method for identifying first-generation perfusion culture media based on existing fed-batch media and feeds. Here, they show that they can obtain culture media that successfull…
Article
Evaluation of HEK293 Cell Growth and Adenovirus Productivity in HyClone™ CDM4HEK293 Medium
Human embryonic kidney 293 (HEK293) cells are widely used in production of recombinant viruses and proteins because of their stable growth, high transfection level, and ability to produce high viral t…