Search results for " surfac" in Articles / App Notes
Article
Evaluating Design Margin, Edge of Failure and Process
The reason the design space alone is misleading is it represents the average surface response as opposed to individual batches, lots, vials, or syringes. The mean response may be safe, but the individ…
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Determining Criticality, Part Two: DoE and Data-Driven Criticality
To generate response surfaces and illustrate second-order (quadratic) relationships between process parameters and CQA. This analysis allows optimal set points for the design space or control space to…
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Milestones and Moderate Progress in 2012 Drug Approvals
The recombinant protein displays terminal mannose residues in its glycocomponent, facilitating direct product uptake by macrophages (the target cell type) via cell surface mannose receptors.
Int…
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Addressing the Challenges in Downstream Processing Today and Tomorrow
Smaller beads with more surface area is the most effective manner to increase capacity (37,38). Other processes that are being utilized include tangential flow filtration that takes advantage of the l…
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Fundamentals of hydrophobic interaction chromatography
This technique separates proteins according to differences in their surface hydrophobicity, and is suitable for the purification of a large range of molecules:
* recombinant proteins and peptides…
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Balancing AAVs Versus LLVs
The prevailing understanding is that serotypes bind to different, or have differential affinities to an array of primary cell surface glycoprotein receptors and secondary receptors.
Pharmace…
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An open bioprocess innovation challenge!
… Learn more about 2022 participants and AI web-based virtual bioreactors, innovative sensor systems, surface that purifies biomolecules by electronic signals, and digitialization tools.
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Understanding Protein Production from Start to Finish
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In protein research, going from idea to pure characterized protein takes multiple steps and techniques. Most scientists working with exploring proteins and developing spe…
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Updating Viral Clearance for New Biologic Modalities
Viral clearance processes and guidance must evolve along with newer biotherapeutic modalities.
By Feliza Mirasol
Ensuring viral clearance (i.e., removal) in downstream purification has becom…
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Next Generation Process Chromatography
The surface area that Fibro exhibits provides immediate binding opportunities at high capacities of the target proteins such as mAbs. This means that a chromatographic cycle that currently takes ~3 ho…