Search results for " recombinant"
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Fermentation for the Future
coli, is the formation of insoluble aggregates of the overexpressed recombinant protein, referred to as IBs. In most cases, the IBs consist largely of the protein of interest, but may also include oth…
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Elucidating Biosimilars Characterization
NIBRT: Differences regarding the approval process for small molecules as compared to recombinant protein therapeutics are reflected in the complexity that must be considered when comparing small-molec…
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Milestones and Moderate Progress in 2012 Drug Approvals
The recombinant protein displays terminal mannose residues in its glycocomponent, facilitating direct product uptake by macrophages (the target cell type) via cell surface mannose receptors.
Int…
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Register to the Chromatography + Filtration Virtual Summit 2024
Learn from presentations, live Q&A, and panel discussions with your peers on recent advances in antibody, antibody variants, recombinant proteins, and gene therapy downstream applications.
Agen…
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Innovative Chromatography Resins Can Improve Purity and Quality
Development of an individual, multi-step chromatography downstream processing (DSP) for every recombinant protein anew increases overall development costs and timelines, and hence prolongs time-to-mar…
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Genetic Vaccine Platforms Demonstrate Their Potential
The same could hold true for protein-based or recombinant protein-based.
Because genetic vaccines trigger their immune response via a fragment of the virus genome, they will conti…
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Can Vaccine Development Be Safely Accelerated?
As an example, he points to the development of subunit vaccines that rely on recombinant DNA to encode a critical subunit of the vaccine that generates a response. There are additional challenges to t…
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Ensuring Viral Safety of Viral Vaccines and Vectors
Because of the risks associated with live and inactivated viruses, namely potential attenuation reversal or failure of inactivation, recombinant viruses have emerged in the role of either vaccines or …
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Affinity chromatography Handbook: Vol. 2 Tagged Proteins
The use of recombinant proteins has increased greatly in recent years, as has the wealth of techniques and products used for their expression and purification. The advantages of using a protein/peptid…
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An Integrated Approach to Ensure the Viral Safety of Biotherapeutics
By Mark Plavsic
Use of continuous cell lines in the manufacture of biological therapeutic products, such as vaccines, recombinant proteins, and monoclonal antibodies, is associated with the concom…