Search results for " recombinant"
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News: Cytiva Adds ELISA Kit to End-to-End HCP Monitoring Capabilities
Cytiva is pleased to announce the new Amersham HCPQuant CHO kit, a generic for detecting host cell protein impurities in drug samples produced in CHO cell lines.
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Advances in Engineering of Protein-Based APIs
Advances in Engineering of Protein-Based APIs
New platform technologies, advanced modeling tools, and addressing patient needs are important developments.
By Cynthia A. Challener
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A Look at the Affinity Chromatography Landscape
“Engineered recombinant Protein A resins with smaller bead sizes are often suitable for bispecific antibodies with Fc regions, while for bispecific molecules without Fc regions, other affinity resins …
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Achieving Process Balance with Perfusion Bioreactors
Advances in single-use technologies, sensors, and cell retention systems facilitate processes designed for the long run.
By Cynthia A. Challener
MG/Stock.Adobe.com
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Scalable Viral Vector Manufacturing
Viruses are much larger than recombinant proteins and antibodies, and therefore tailored purification technologies must be used. The scalability factor must be considered as well. We strongly recommen…
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Scaling Up Novel Therapies
In addition, he says, it will speed up and allow for screening of a much larger number of variants for mAbs, bispecifics, trispecfics, fragments, and recombinant proteins. For some cell therapies, the…
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A Look into the Future of Biopharmaceutical Quality
…L): Over the past 50 years, the industry has grown, especially due to advances in areas such as recombinant DNA and hybridoma technology, and more recently gene and cell therapies. As these advanceme…
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Industry Adoption of Single-Use Systems Remains Low
Abzena, a CDMO, conducts development and GMP manufacture of antibody drug conjugates at its Bristol facility and conducts development and GMP manufacture of monoclonal antibodies and other recombinant…
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Preclinical Evaluation of Product Related Impurities and Variants
Preclinical Evaluation of Product Related Impurities and Variants
The approaches for sample preparation of preclinical evaluation of safety and efficacy are addressed taking into consideration the s…
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Techniques for Improving Process Development for Exosome-Derived Therapeutics
Luminal payloads can be introduced through endogenous loading by recombinant cell lines or through ex vivo loading. One can move to the next level of sophistication by changing the surface of the exos…