Search results for " DoE" in Articles / App Notes
Article
Upstream PD Time-Saver: Optimize Early
Click here to read the article >>
Optimization is key to achieving a high-producing CHO cell culture. Identify the right combination of culture medium, feed supplements, and feeding strategy …
Article
Faster Flavivirus Vaccine Production
Viral vaccines need to be produced fast and in large quantities. Routine immunizations and preventive campaigns, like stockpiling in response to emergencies, involve millions of doses, and speed is es…
Article
Leveraging Computational Models of Glycosylation for Biopharma QA
Close collaboration between academic and industrial groups is vital to ensuring glycosylation models are fit for deployment.
By Ioscani Jiménez del Val
Good Studio/S…
Article
Optimization of Fed‑Batch Culture Conditions for a mAb‑Producing CHO Cell Line
This application note describes a broadly applicable and efficient workflow toward finding the optimal feed combination for the best-performing fed-batch processes.
An IgG1-producing CHO cell …
Article
Gain Efficiency in Process Development
The development of efficient manufacturing processes is a necessity for cost-effective production of biopharmaceuticals. By carefully designing and evaluating your experiments, sufficient informatio…
Article
Modeling Bioreactor Performance
With the rapidly increasing accessibility of high-speed computing power, he does add, though, that multiphase and higher resolution models are being used more frequently.
In addition, many of the …
Article
Tools for Continuous Bioprocessing Development
A paper from ETH Zurich (funded by Novartis) demonstrated that geometric similarity fundamentally does not allow for scale invariance (from 3 L to 15,000 L) of kLa, shear stress, and mixing time simul…
Article
Implications of Cell Culture Conditions on Protein Glycosylation
The authors present a review of the techniques commonly used for glycosylation analysis.
By Michiel E. Ultee, PhD, Dr. Richard Easton
This article reviews the implications of cell-culture co…
Article
High-Throughput Process Development in an Historical Environment
Presentations, discussions, and information-sharing on modern bioprocess technology and high-throughput process development (HTPD) in an historical and culturally enriched environment is the essence…
Article
QbD and PAT in Upstream and Downstream Processing
BioPharm: Given the inherent variability in biologics manufacturing, how does QbD improve process understanding and control? What are the limitations of QbD in upstream bioprocessing?
McKnight (Ge…