Search results for " cell"
Article
Improving Upstream Predictability
By Agnes Shanley
In the earliest days of biotech, developers often struggled to sustain conditions that would optimize cell health and product yield. Today, better understanding of cells and …
Article
Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The white paper includes a brief discussion around modern vaccine processes, followed by a case study showing the scale-up of upstream and downstream processes for the production of a cell based live …
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Achieving Process Balance with Perfusion Bioreactors
With recent availability of perfusion bioreactors and novel cell retention technologies, there is a renewed interest in perfusion cell culture,” notes Peter Levison, executive director of business dev…
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Science Focus Fuels Successful Process Development for Startups
Emerging biopharma companies working to develop novel gene and cell therapies face even greater obstacles. They lack access to revenue streams from existing drug sales to fund their process developmen…
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Gene Therapies Push Viral Vector Production
“In ex-vivo, cells are modified outside the patient’s body and the corrected version is transplanted back into the patient. Opposite of ex-vivo is what we call in-vivo, where cells are treated inside …
Article
Platform Approach Speeds Process Development
… recombinant monoclonal antibodies is dependent on high performing bioprocesses using mammalian host cells. Chinese hamster ovary (CHO)-based cell culture platforms should combine state-of the-art te…
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Host-Cell Protein Measurement and Control
Recombinant therapeutic proteins are usually produced by genetically-modified prokaryotic or eukaryotic host cells using cell culture/fermentation technology (2). Genetic engineering allows the host c…
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Platform Technologies Improve Protein Expression
In addition, new technologies for genomic engineering of cells for the production of therapeutic proteins are “opening up a new world of possibilities to tailor-make protein-based drugs with appropria…
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Unifying Continuous Biomanufacturing Operations
By Randi Hernandez
When human cells travel throughout the body, they are constantly being influenced by the environment around them. The most efficient upstream processing systems in biologics man…
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Ensuring Viral Safety of Viral Vaccines and Vectors
Since then, better safety measures and the use of established and characterized cell lines have improved safety in biologicals. To date, no infectious virus has been transmitted to a patient by a cell…