Search results for " cell" in Articles / App Notes
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Industry Adoption of Single-Use Systems Remains Low
Additionally, in 2016, the company announced a $7-million expansion project in Westborough, MA (5), where a range of single-use products, including cell growth bags, will be manufactured. Other recent…
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Development of Purification for Challenging Fc-Fusion Proteins
As tested on three Fc-fusion proteins, this process demonstrates high process yield, improved clearance of HMWs and LMWs, and efficient reduction of host cell proteins (HCP) and DNA as well as robust …
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Analysis of Glycosylation in Biosimilars
The pattern cannot be predicted from the genetic code, and the exact nature of the glycosylation depends on the cells and the conditions in which they are cultured. This adds an additional layer of co…
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mAbs to Watch in 2016
The PD-L1 checkpoint inhibitor is being investigated for the treatment of various solid tumors, including indications for non-small cell lung cancer (NSCLC), bladder cancer, renal cell carcinoma, and …
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Bracing for a Future Wave of Advanced Therapies
Buoyed by the regulatory approval of several cell and gene therapy (CGT) products for difficult-to-treat diseases, the US biopharma industry is now bracing for a new wave of CGTs in the near future as…
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Top Process Development Trends for 2021 and a Look into 2022
Next-Generation Therapeutics: Improvements & Challenges
Advanced therapeutic medical products (ATMPs)—which are based on genes, tissues, or cells—continue to gain traction. They are further categor…
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Virus-like Particles as Therapeutic Moieties of the Future
At least 110 VLPs have been constructed so far from 30 different virus families (1), and a variety of expression systems ranging from bacteria to mammalian cell systems have been used for their produc…
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A Look at the Affinity Chromatography Landscape
…ein-based biologics, but a wide range of other biomolecules, from viral vectors and nucleic acids to cells.
Beyond impurity removal for “simple” proteins
Affinity chromatography in biologics …
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Techniques for Improving Process Development for Exosome-Derived Therapeutics
Would you please start by giving us a short overview of what are exosomes and the benefits they may have in clinical applications?
Exosomes are cell-derived vesicles produced by living cells and f…
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The New World of Biopharmaceutical Manufacturing
Single-use systems must be tested extensively to ensure that their materials of construction do not inhibit cell growth or release chemicals into the product stream during bioprocessing. Biomanufactur…