Search results for " cell" in Articles / App Notes
Article
A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAbs at Large Scale
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As process intensification is adopted into large-scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quic…
Article
A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAb at Large Scale
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As process intensification is adopted into large-scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quick…
Article
Production of Recombinant Adeno-associated Virus Vectors Using Microcarrier Culture of HEK293T Cells
As of March 2020, more than 4310 gene therapy clinical trials have been performed worldwide, with only 518 of them in Phase III and Phase IV. As the gene therapy projects enter clinical Phase III or g…
Article
Controlling Cell Culture Process Variability Through Supplier-Enabled Data Management and Analytics
In drug development and manufacturing, variability in raw materials presents high risks to the success of processes and products. When raw material variability issues arise, manufacturers and supplier…
Article
Impact of Media Components on CQAs of Monoclonal Antibodies
Mammalian cells meet these criteria quite efficiently by virtue of their post-translation modification system, and this has made them a dominant production system for the biopharmaceutical industry. M…
Article
Generating a Fully Processed Antibody
…r additional post-translational modifications not typically performed by Chinese hamster ovary (CHO) cells, and more recently, numerous different multispecific antibody platforms. Each of these class…
Article
New Therapies Present Scaling Challenges
By Feliza Mirasol
The approval of emerging biologic-based therapeutics—such as cell and gene therapies—presents challenges and decisions for drug companies looking to increase the manu…
Article
Downstream Processing for Cell-Based Therapies
Rafiq, Fernanda Masri
With increasing numbers of advanced therapies—including cell and gene therapies—entering early- and late-stage clinical development, significant focus has been directed towar…
Article
Patenting Prospects for Cell-Based Therapies
By Kevin Noonan
Treatment using cell-based therapies is a rapidly advancing area of clinical research and development. It is also one that involves significant investment and, therefore, can b…
Article
Tools for Continuous Bioprocessing Development
For instance, in cell culture, the typical biopharmaceutical company uses at least a dozen different platforms, including shallow-well microtiter plates; deep-well microtiter plates; shake flasks; ben…