Search results for " cell" in Articles / App Notes
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
The presence of serum, culture harvest viability, turbidity, cell lysis reagents, contaminant DNA levels, and residual transfection agents are all upstream factors. Overall process scalability and rob…
Article
Implementation of Raw Material Control Strategies in the Manufacture of Single-Use Bioprocessing Containers
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This article discusses efforts to limit polymer degradation without significantly impeding cell growth. The authors were able to show that a single resin can be converted to films that lead…
Article
Concentrating Feed—an Applicable Approach to Improve Antibody Production
These approaches did not affect product quality and were effective for multiple cell lines and applicable for large-scale manufacturing.
Recombinant protein production in the biopharmaceutical …
Article
Improving Upstream Predictability
By Agnes Shanley
In the earliest days of biotech, developers often struggled to sustain conditions that would optimize cell health and product yield. Today, better understanding of cells and …
Article
Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The white paper includes a brief discussion around modern vaccine processes, followed by a case study showing the scale-up of upstream and downstream processes for the production of a cell based live …
Article
Achieving Process Balance with Perfusion Bioreactors
With recent availability of perfusion bioreactors and novel cell retention technologies, there is a renewed interest in perfusion cell culture,” notes Peter Levison, executive director of business dev…
Article
Science Focus Fuels Successful Process Development for Startups
Emerging biopharma companies working to develop novel gene and cell therapies face even greater obstacles. They lack access to revenue streams from existing drug sales to fund their process developmen…
Article
Gene Therapies Push Viral Vector Production
“In ex-vivo, cells are modified outside the patient’s body and the corrected version is transplanted back into the patient. Opposite of ex-vivo is what we call in-vivo, where cells are treated inside …
Article
Platform Approach Speeds Process Development
… recombinant monoclonal antibodies is dependent on high performing bioprocesses using mammalian host cells. Chinese hamster ovary (CHO)-based cell culture platforms should combine state-of the-art te…
Article
Host-Cell Protein Measurement and Control
Recombinant therapeutic proteins are usually produced by genetically-modified prokaryotic or eukaryotic host cells using cell culture/fermentation technology (2). Genetic engineering allows the host c…