Search results for "biopharm"
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Immediate, Flexible Capacity with Hydrated Buffers and Process Liquids
Fluids used in bioprocessing are typically prepared in-house by hydrating powders purchased from suppliers. Historically, bioprocessing facilities have prepared buffers and process liquids in-house …
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Hybrid Bioprocessing: A Q&A with Andrew Sinclair
Process Development Forum speaks about hybrid bioprocessing with Andrew Sinclair, President and Founder of BioPharm Services
How would you define hybrid bioprocessing?
Hybrid processing is n…
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Managing Residual Impurities During Downstream Processing
There is, however, no set of standard assays for the determination of contaminants such as HCPs during manufacturing because each biopharmaceutical process is unique and results in unique impurities; …
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Unifying Continuous Biomanufacturing Operations
The success of a truly integrated continuous processing platform relies on the collaborative efforts of upstream and downstream specialists.
By Randi Hernandez
When human cells travel throug…
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Fusion Proteins Pose Manufacturability Challenges
…ines and a longer half-life,” explains Steven Chamow, a principal with Chamow & Associates, a biopharmaceutical industry consultancy.
Specifically, two or more proteins are joined in one polypept…
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Witnessing Major Growth in Next-Generation Antibodies
Including next-gen antibodies in pharma pipelines is considered essential for future success.
By Cynthia A. Challener
Next-generation antibodies are designed to be more specific and are ofte…
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Downstream Processing for Cell-Based Therapies
By Qasim A. Rafiq, Fernanda Masri
With increasing numbers of advanced therapies—including cell and gene therapies—entering early- and late-stage clinical development, significant focus has been …
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Mechanistic Modeling of Preparative Ion-Exchange Chromatography
By Anurag Rathore, Vijesh Kumar
Among the various downstream processing unit operations that are used for purification of biotech products, chromatography is uniquely capable of providing resolu…
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Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
Biopharmaceuticals are produced in cell cultures, and the final product is much more than a DNA sequence. These products are subject to post-translational modifications such as glycosylation, phosphor…
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Single-use Bioreactors Have Reached the Big Time
Challener
Single-use bioreactors available from various vendors today are robust and provide the high-performance necessary for commercial manufacturing of biopharmaceuticals. Significant advances…