Search results for " attribute" in Articles / App Notes
Article
A Look at the Affinity Chromatography Landscape
“Use of affinity chromatography has removed some of the burden on the purification steps downstream of the affinity step, allowing the focus to be directed toward specific attributes such as enrichmen…
Article
Achieving Process Balance with Perfusion Bioreactors
“It is important to design a process with a balanced feed rate that ensures the target is reached without compromising the critical quality attributes of the product,” he states.
Running longer pr…
Article
Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
Thus, glycan structure is a critical quality attribute (CQA) that must be monitored during drug manufacturing.
Glycan composition profiling is commonly used to track the structural diversity of…
Article
A Look into the Future of Biopharmaceutical Quality
Schniepp (RCA): I think the quality unit will evolve to be a more hands-on review of the product attributes. The quality unit will need to be equal partners with manufacturing to be able to release pr…
Article
The Challenge of Disruptive Technologies in Bioprocessing
“Advanced automation also involves the use of trend analysis and correlations between ‘simple’ measurements and ‘complex’ quality attributes,” he says.
“This all helps to lower the cost of the …
Article
Biopharma Says It Has an Evolution in New Technologies and Processes
A significant roadblock to the implementation of continuous bioprocessing is the need for improved process analytics to measure critical quality attributes (e.g., protein function) in real time. Anoth…
Article
Making the Move to Continuous Chromatography
“PAT and analytical methods that allow a process to continue running while providing feedback on critical quality attributes of a particular purification step have not evolved at the same rate as thei…
Article
Techniques for Improving Process Development for Exosome-Derived Therapeutics
A myriad of attributes can be studied for a given population of exosomes. We want to focus on the ones that relate to the functional characteristics of exosomes and how they might behave from a safety…
Article
Reducing Cross-Contamination Risks in Process Chromatography
All of the attributes of single-use technologies--reduced process time, faster equipment turnaround, greater manufacturing flexibility, and reduced risk of cross contamination--apply to chromatography…
Article
Platform Technologies Improve Protein Expression
“These approaches offer avenues for designing better fit-for-purpose molecules not only in terms of their activity and safety, but also with respect to desirable CMC attributes,” says Voldborg.
Th…