Search results for " design" in Posters
Poster
Strategies for optimized cell culture media: Effectively using design space to influence product quality
Here we highlight a statistical design strategy to optimize cell culture media to influence the charge variant profile of a mAb produced in CHO DG44 cells.
Media optimization requires incorp…
Poster
Evaluation of Protein A resin lifetime during extensive use (overloading) in continuous chromatography mode
This application note compares the performance of MabSelect SuRe pcc resin designed for continuous capture of mAbs, with the conventional high-capacity Protein A resin MabSelect SuRe LX. The study was…
Poster
FlexFactory™ Automation
To enable compliance with regulatory requirements, FlexFactory Automation is designed according to GAMP™ 5 guidelines (ISPE).
Poster
Perfusion Media Development for Scalable Processes
The nutrient-rich but balanced media should be designed to support very low cell-specific perfusion rates (CSPR) that minimize media consumption while maximizing viable cell days and productivities. O…
Poster
Opportunities, Challenges, and Economic Drivers for Start-to-Finish Continuous Biomanufacturing
Adopting advanced process design will need an accurate business case and risk profile for implementation. Within the risk profile, assurance of patient safety and supply through product quality demons…
Poster
Rapid Process Development of a CIEX Step for a Biosimilar
By providing the process development support, aggressive timelines could be addressed, which resulted in an accelerated progression of bioprocess design to reduce timelines.
The aim was to select t…
Poster
A Next Generation Protein A Chromatography Resin for Improved Productivity and Bioburden Control
This poster presents a newly designed, high-capacity Protein A resin, MabSelect™ PrismA, which offers alkali stability on par with ion exchange and hydrophobic interaction chromatography resins, enabl…
Poster
Development of DoE based fed-batch strategies for high-producing CHO cell cultures
Fed-batch culture is commonly employed to maximize cell and product concentrations in upstream mammalian cell culture processes. Typical standard platform processes rely on fixed-volume bolus feedin…
Poster
Unlocking the potential for efficiency in downstream bioprocesses
It also shows how implementation of efficient process designs can overcome traditional downstream bottlenecks, such as time-consuming column packging, cleaning of equipment, and laborious buffer tank …
Poster
Optimizing productivity on high capacity protein A affinity medium
This application note summarizes studies on designing customized loading strategies to shorten the average residence time when using MabSelect SuRe LX, with the goal of improving productivity without …