Search results for " resins" in Articles / App Notes
Article
The Challenge of Disruptive Technologies in Bioprocessing
“The Thermo Scientific POROS CaptureSelect technology provides highly selective affinity resins with antibody-like specificity, which can significantly improve the biomolecule purification process, ma…
Article
Single-Use for Downstream Chromatography: Benefit or Hindrance?
Resin fouling
Another unmet need for biopharmaceutical manufacturers is technology that reduces the cost of resins (3), to allow for greater use of single-use systems to address the resin fouling t…
Article
Exosome isolation by tangential flow filtration and size exclusion chromatography
We demonstrate a scalable workflow for the isolation of exosomes—a type of extracellular vesicle with significant potential for targeted drug/gene delivery. For research and development and di…
Article
Chromatography for the Diversified Antibody Pipeline
The HIC resins also demonstrated as good aggregate removers—we have the usual suspects such as aggregates, post end proteins, and tricky wholesome proteins. Polishing may be more challenging and will …
Article
Cytiva Advances Fiber Chromatography Technology with New Launch
The launch of HiScreen Fibro PrismA, the company’s newest product for early mAb purification process development strengthens Cytiva’s new fiber-based Protein A platform.
On Jan. 27, 2021, Cyti…
Article
Updating Viral Clearance for New Biologic Modalities
Next-gen biopharma processing
Recent innovations, particularly in filter membranes and chromatography resins, have further helped to improve viral clearance performance.
“In general, chromatog…
Article
A Closer Look at Affinity Ligands
Using traditional resins with small pore size leads to low binding capacity because of very low diffusion rates into the pores of the resin. LV particles are also exceptionally sensitive to pH, salt c…
Article
Chromatography innovations for the diversified antibody pipeline
MabSelect™ VH3 resins provides efficiency in capture of bispecific antibodies and antibody fragments such as Fab, scFv, and VHH. Discover how we’re supporting the diverse antibody pipelines with chrom…
Article
Report from the 6th International HTPD Conference
HTPD was mainly limited to 96-well plates filled with chromatography resins used for resin selection and initial screening of running conditions. Since then, HTPD in chromatography applications has be…
Article
As the therapeutic pipeline diversifies, chromatography toolboxes are expanding.
Development beyond traditional monoclonal antibodies (mAbs) is increasing, and today, we see antibody variants like multispecific and bispecific antibodies and antibody fragments. In mAb proc…