Search results for " capacity" in Articles / App Notes
Article
Purification of Plasmid DNA
By switching to modern chromatography resins, Cobra Biologics was able to increase binding capacity and flow rates up to 50% to address the increasing demands for high quality plasmid DNA.
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The Evolving Role of Starting Materials in Cell and Gene Therapy
Apheresis center capacity, donor network access, sample handling expertise, and quality control systems all contribute to the ability to achieve reproducible starting material quality and efficacy.
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Overcome Chromatography Challenges with Fiber Adsorbents
Bioprocessing evolution highlights the desire for new purification technologies that offer greater flexibility for use—from research and early process development through large-scale commercial prod…
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Can You Trust a Machine for Downstream Bioprocess Buffer Preparation?
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- Is automated buffer preparation a solution to the dilemma of balancing increased production capacity against limited footprint expansion alternatives?
- Can you trust a machine for dow…
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Intensified Chromatography Strategies
The blockbuster drug era is over and drug manufacturers are now striving for a more diversified portfolio by targeting a greater number of monoclonal antibody (mAb) products at lower production volu…
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Design Considerations for a Commercial Cell and Gene Therapy Facility
What to consider
“There are multiple considerations to take into account, perhaps most important, though, are capacity utilization at full scale and space efficiency,” says Phil Vanek, general m…
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Addressing the Complex Nature of Downstream Processing with QbD
“Polishing steps such as ion exchange, hydroxyapatite, and hydrophobic interaction chromatography can be more heavily influenced by pH, conductivity, loading capacity, residence time, and temperature,…
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Single-Use for Downstream Chromatography: Benefit or Hindrance?
Single-use technology is gaining ground in downstream bioprocessing, but challenges stall further adoption.
By Feliza Mirasol
ARTMOIS/STOCK.ADOBE.COM
Biopharmaceutical manufactu…
Article
What’s New in Upstream Technologies
The biomass capacity offers a broad measurement range and bubble correction factors for gas bubble density and enables reliable online measurements in high aeration and agitation environments. Online …
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Science Focus Fuels Successful Process Development for Startups
In fact, emerging biopharma firms working in the fields of cell and gene therapy face significant competition for contract manufacturing capacity, according to Krishnan. It is important to begin the s…