Search results for " capacity" in Articles / App Notes
Article
Fusion Proteins Pose Manufacturability Challenges
The unique structures of fusion proteins lead to expression, heterogeneity, and stability issues.
By Cynthia A. Challener
Fusion proteins are engineered proteins that contain domains from di…
Article
Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
They are able to flow at fast rates, albeit with low binding capacity.
Taken together, upstream and downstream process innovations can be packaged into an automated, continuous, small-footprint an…
Article
Single-use Bioreactors Have Reached the Big Time
The decision to use disposable bioreactors is now driven by commercial rather than technological considerations.
By Cynthia A. Challener
Single-use bioreactors available from various vendors…
Article
Reconciling Sensor Communication Gaps
Think of permittivity as the capacity of cells to hold an electrical charge, analogously to the operation of an electronic capacitor. Living cells hold charges while dead cells or debris do not. Where…
Article
The Tide Stays High
Many CDMOs have told PharmSource that they are operating near capacity, and customers may have to wait as much as six months for a manufacturing slot.
The significance of external funding can be s…
Article
Managing Risk in Raw Material Sourcing
Vendor selection and materials testing are complex enough, but in today’s volatile environment, risk mapping and monitoring are also crucial.
By Agnes Shanley
Choosing excipients and supplie…
Article
Modeling Bioreactor Performance
“Typically all models are useful in some capacity, but it is important to understand the limits of the model you are using,” he concludes.
Article
Perfusion in the 21st Century
As a result, fed-batch is often preferred in existing plants with installed capacity, whereas in newer, multiproduct facilities, perfusion in single-use equipment provides favorable economics.
Ref…
Article
Affinity Chromatography Handbook in 3 Volumes
The technique offers high selectivity, hence high resolution, and usually high capacity for the protein(s) of interest. Purification can be in the order of several thousand-fold and recoveries of acti…
Article
Affinity chromatography Handbook - Vol. 3: Specific Groups of Biomolecules
The technique offers high selectivity, hence high resolution, and usually high capacity for the protein(s) of interest. Purification can be in the order of several thousand-fold and recoveries of acti…