Search results for " fed-batch"
Article
Biomanufacturing: Demand for Continuous Bioprocessing Increasing
Negative assessments from within the industry of continuous perfusion fed-batch processing overall may reflect a lack of direct exposure or experience with continuous technology.
In BioPlan’s a…
Article
Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
…roductivity with their WuXiUP continuous perfusion-based processing platform compared to traditional fed-batch, which enables 1000-L single-use bioreactors to produce the same amount as 10,000-L stai…
Article
Cell-Culture Advances Test Bioreactor Performance Models
He points to the higher cell densities in perfusion mode, which result in increased oxygen demand in a higher viscosity solution with potentially more cell-free biopolymers and lipids than a fed-batch…
Article
Scaling Up Novel Therapies
One way they do this, he says, is by “scaling out,” intensifying processes, for example by using fed-batch and perfusion on the upstream side, and multicolumn operations, whether it’s just higher cycl…
Article
Impact of Media Components on CQAs of Monoclonal Antibodies
CHO cells in fed-batch mode at low glutamine (17% (w/w) hampered the rate of deamidation up to 40%. Polyols at high concentrations displayed a protective effect on oxidation. Addition of 0.01% (v/v) P…
Article
Innovations in Perfusion Bioprocessing
In this study, we present a method for deriving perfusion culture media by leveraging existing fed-batch media and feeds.
Furthermore, we illustrate the successful transfer of the develop…
Article
A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAb at Large Scale
Read more>>
As process intensification is adopted into large-scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quickly follow…
Article
Explore the Process Intensifier App
Explore alternatives to intensify your processes >>
How do you know if an intensification approach will give you advantages over your current biomanufacturing process, and how do you choose the …
Article
The Importance of Process Intensification and PAT for Achieving Real-Time Release
As the industry has matured, effective manufacturing platforms and analytical tools and technologies appropriate for fed-batch manufacturing in stainless-steel or single-use bioreactors have also adva…
Article
Developing a Continuous Large-Scale Perfusion Cell Culture Process
Click here to read more >>
Perfusion processes enable continuous operation over extended periods of time by constantly providing fresh nutrients for the cells and simultaneously removing spent…