Search results for " fed-batch"
Article
Developing a Continuous Large-Scale Prefusion Cell Culture Process
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Perfusion processes enable continuous operation over extended periods of time by constantly providing fresh nutrients for the cells and simultaneously removing …
Article
Improving Upstream Predictability
“We’ve consistently been seeing titers in the range of 4–6 g/L in [monoclonal antibody] mAb fed-batch processing within a chemically defined media environment. This environment, in turn, results in mo…
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Best Practices for Selecting a Top-Quality Cell Line
Irina Shi - Stock.Adobe.com
Leveraging automation and a step-by-step approach are keys to success.
By Cynthia A. Challener
Cell lines determine the performanc…
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Moving PAT from Concept to Reality
Intensified processes are much more complex than conventional fed-batch processes and therefore require tighter monitoring and control, adds Grieb. “PAT and automation do not only provide this, but al…
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Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
While the multiple attributes method gains ground and traditional lab methods improve, broad efforts are underway to determine biopharmaceuticals’ most significant critical quality attributes and en…
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Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
…y applicable and efficient workflow for finding the optimal feed combination for the best-performing fed-batch processes.
Understanding the Regulatory Environment
Regulatory-focused article…
Article
Perfusion Culture Using TFF or ATF as Cell Retention Method
Compared with batch or fed-batch processes, perfusion processes also allow cells to be maintained in exponential growth phase for an extended period of time and reach higher viable cell densities.
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State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
When asked about significant concerns with continuous perfusion versus upstream fed-batch operations, over two-thirds of respondents (68.9%) cited "Process development control challenges" with perfusi…
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Optimizing Late-Stage and Commercial Cell-Culture Processes
This resulted from the introduction of parental cell lines better suited to modern fed-batch processes and the development of better bioreactor processes, including control strategies for pH, carbon d…
Article
Platform Technologies Improve Protein Expression
“With these expression systems, it will be possible to conduct much longer fed-batch runs and significantly increase the amount of product that can be made from each production run.” The center has al…