Search results for " fed-batch" in Articles / App Notes
Article
Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
While the multiple attributes method gains ground and traditional lab methods improve, broad efforts are underway to determine biopharmaceuticals’ most significant critical quality attributes and en…
Article
Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
…y applicable and efficient workflow for finding the optimal feed combination for the best-performing fed-batch processes.
Understanding the Regulatory Environment
Regulatory-focused article…
Article
Perfusion Culture Using TFF or ATF as Cell Retention Method
Compared with batch or fed-batch processes, perfusion processes also allow cells to be maintained in exponential growth phase for an extended period of time and reach higher viable cell densities.
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State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
When asked about significant concerns with continuous perfusion versus upstream fed-batch operations, over two-thirds of respondents (68.9%) cited "Process development control challenges" with perfusi…
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Optimizing Late-Stage and Commercial Cell-Culture Processes
This resulted from the introduction of parental cell lines better suited to modern fed-batch processes and the development of better bioreactor processes, including control strategies for pH, carbon d…
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Platform Technologies Improve Protein Expression
“With these expression systems, it will be possible to conduct much longer fed-batch runs and significantly increase the amount of product that can be made from each production run.” The center has al…
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Being Thorough When Transferring Technology
In the case of microbial fermentation, heating and mass transfer demands can often be controlled by the fed-batch feed rate. Thus, you want to use a feed profile at the bench or pilot scale that will …
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Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
Traditional manufacturing processes for biologics make use of large, fed-batch reactors and oversized chromatography columns that end up wasting time or material. Alternatively, upstream process scale…
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Single-use Bioreactors Have Reached the Big Time
“Today, a continuous process can last significantly longer than current fed-batch processes, which means that there are higher expectations and a need for a high-level of sensing analytics, providing …
Article
Modeling Bioreactor Performance
Model effectiveness is determined by the quality and composition of the data inputs.
By Cynthia A. Challener
Bioreactor design, including the geometry of the tank and impeller and the locati…