Search results for " inline" in Articles / App Notes
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
She also notes that the design of the scale-X bioreactor has been shown to provide significantly higher yields than alternative adherent-cell based systems for virus production, while the inline produ…
Article
2019’s Top Bioprocessing Trends and What to Expect in 2020
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Getting it Right from the Start in the Drug Development Process
Monitoring and Control of Inline Dilution Processes
Increase Efficiency in Experimentation with Design of Experiments
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Article
The Evolving Role of Starting Materials in Cell and Gene Therapy
… cleanrooms and isolator hoods as well as through the use of closed culturing systems and automated, inline quality attribute monitoring.
Contamination isn’t the only risk to starting material …
Article
How to Adapt Biomanufacturing Processes
As the need for more complex molecules drives a new era of biomanufacturing, there is an increased focus on developing processes with improved security, yield, and process economy. Companies working…
Article
Cell-Culture Advances Test Bioreactor Performance Models
“Relatively recent application of PAT, such as Raman spectroscopy and biomass probes for inline sensing, are now providing more complete data on cell-culture performance and enabling better, more time…
Article
Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
The group is also using return on investment analysis as well as internal rate of return, payback, and net present value to assess the business case for inline testing and RTR.
Among other questio…
Article
Four Purification Steps with Buffer Dilutions in One Go? No Problem!
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Free up time by automating the protein purification and by reducing manual interactions. Learn how Shin Isogai at Biozentrum, Basel, harnesses automation to puri…
Article
Achieving Process Balance with Perfusion Bioreactors
Appropriate flow sensors (either clamp-on or inline) to measure media feed or permeate and viable cell-density probes are therefore important.
An extra-large retention port is also needed in a per…
Article
Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
…uid chromatography (HPLC or UHPLC, respectively) coupled to fluorescence detection (FLR), often with inline mass spectrometry (MS). Typically, dextran ladder mobility (GU values) and mass data (m/z) …
Article
The Challenge of Disruptive Technologies in Bioprocessing
“Various operational challenges and process analytical technologies for inline/ at-line/on-line controls still need to be worked out to achieve success in continuous bioprocessing. This is a highly re…