Search results for "multivariate" in Articles / App Notes
Article
Determining Criticality, Part Two: DoE and Data-Driven Criticality
To do this, multivariate studies must be performed to account for the complexities of interactions when several CPPs vary across their control ranges.
Design spaces can be developed for each un…
Article
Essentials in Establishing and Using Design Space
Data analysis and transfer function generation
A multivariate analysis software application needs to be used to analyze the data, eliminate any outliers, determine statistically significant fa…
Article
Download your Mechanistic Modeling eBook
The ability to anticipate and model scale effects is another advantage of mechanistic modeling over multivariate data analysis (MVDA). Mild extrapolations are also covered in the mechanistic modeling …
Article
Gene Therapies Push Viral Vector Production
Gene Therapies Push Viral Vector Production
Viral vectors show promise as a delivery mechanism for gene therapy, but which virus types are commercially viable?
By Feliza Miraso…
Article
Improving Upstream Predictability
“Using automation, process analytical technologies (PAT), and advanced multivariate analysis has enabled the industry to control process performance and product quality more closely than ever before,”…
Article
Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
High-throughput techniques such as micro-bioreactor systems are another enabling technology, which, in combination with design of experiments (DoE) and multivariate data analysis (MVDA), support a qua…
Article
Achieving Process Balance with Perfusion Bioreactors
“Multivariate data analysis (MVDA) using software such as our SIMCA online system allows efficient process control and early fault detection by looking for differences from the ‘golden batch’,” Adams …
Article
Understanding Validation and Technical Transfer, Part 3
Multivariate analysis and evaluations of interactions among various process parameters, for example drying time, temperature, and particle size, can also show whether the process is operating within i…
Article
Leveraging Data for Better Biopharmaceutical Process Control
Instead of putting effort into unspecific and insensitive methods pushed to their analytical limits, the multi-parametric character of all PAT methods was explored with multivariate analysis to provid…
Article
Single-use Bioreactors Have Reached the Big Time
Recipe functions and data acquisition and analysis capabilities, including most recently multivariate data analysis, allow for effective monitoring of bioprocesses and provide greater confidence in th…