Search results for " throughput"
Article
Strategizing for Rapid Changeovers in Biologics Manufacturing
“This approach affords the opportunity to increase facility throughput,” he says. A phased approach allows for proper and thorough cleaning as the process completes, agrees Husain. In addition, all su…
Resource
Protein A Fiber Chromatography from Research to Scale-up and Manufacturing of Monoclonal Antibodies
Productivity, throughput, buffer consumption, and purification performance will be compared to traditional Protein A column chromatography.
Article
Addressing mAb Purification Bottlenecks with Rapid Cycling Chromatography
The rapid purification enables higher throughput in research and process development, and the technology opens up new opportunities for cost efficient single-use chromatography in large-scale commerci…
Article
2019 HTPD Conference is Approaching. What Happened Last Time?
The 5th international conference devoted to high-throughput process development (HTPD) and smart PD will take place on November 4–7, 2019 in Porto, Portugal.
HTPD 2019 will cover process develo…
Article
What’s New in Upstream Technologies
Integrated online biomass measurement
Sartorius Stedim Biotech (SSB) added an integrated online biomass measurement to its ambr 15 fermentation and ambr 250 high throughput systems for microbial a…
Article
Modeling and Miniaturization: Key Topics at Successful HTPD Conference
Modeling and miniaturization were two key take-home messages from the 4th High Throughput Process Development (HTPD) conference organized in October 2017 in Toledo, Spain. The conference brought tog…
Article
Viral Clearance Challenges in Bioprocessing
“Current filters can be used in this application, but they were not designed to run under continuous and high throughput conditions like those required for media supply,” he observes. Filter vendors a…
Article
High-Throughput Process Development in an Historical Environment
As an example, John Welsh from Merck presented a collaboration with Cytiva on the development of the next- generation multimodal chromatography resins and how high throughput techniques and different …
Article
Challenges of Protein Aggregation During Purification
Currently, high throughput screening techniques are used during the candidate selection phase to select a construct (protein) that is less prone to aggregation, as well as a cell line and cell culture…
Article
Predicting Progress in Protein Aggregation
Evaluating the formulability of protein-based drugs
There have also been significant advances in analytical methods for the determination of protein aggregation, including high throughput capillary…