Search results for "bioreactor" in Articles / App Notes
Article
Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
…e quantities of cells in a very short period of time and then using that to either inoculate larger bioreactors or run in a continuous manner. That's where PAT comes in handy.
Raman is the prim…
Article
New Therapies Present Scaling Challenges
Bioreactor size can be increased (scale up), or the number of bioreactors used can be increased (scale out). In addition, mammalian cell culture technology has advanced such that producing multi-kilog…
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Industry Adoption of Single-Use Systems Remains Low
“It is far more common today that biopharma manufacturers are building small economical facilities with several 2000-L single-use bioreactors--20 years ago, the companies were building a facility with…
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Flexible Facilities for Viral Vector Manufacturing
For example, for Duchene muscular dystrophy, the need (at current viral titers and downstream process recoveries) is about 200 L of production bioreactor culture per patient.” The batch size influence…
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Making the Move to Continuous Chromatography
Continuous chromatography systems are designed to be loaded continuously, which is a useful approach when the purification step is connected to an upstream perfusion bioreactor. There are several diff…
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Hybrid Bioprocessing: A Q&A with Andrew Sinclair
With the improvements and the rise of SU equipment bioreactors, containers, and physical transfer, a lot of the complexity is removed and even with some reusable equipment, we can still achieve the fa…
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Combining Microbioreactors and Advanced Statistical Techniques to Optimize a Platform Process for a New Host-Cell Line
First, the availability of high-throughput miniature bioreactors has made it possible to evaluate many more conditions. This has enabled design of experiment (DoE) approaches, such as response surface…
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Best Practices in Qualification of Single-Use Systems
Aseptic connector devices, mixer bags, storage bags, and bioreactors followed. Currently, single-use systems (SUS) also include disconnectors, disposable filling needles, and sensors. The technology i…
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Evaluating the Use of Continuous Chromatography
… is a useful approach when the purification step is connected to an upstream perfusion or fed-batch bioreactor, and, by having two or more columns in the loading zone, you can overload the first colu…
Article
Simplify-bioreactor scale up and scale down: applications and tools
In this article we present the theory for bioreactor scaling and propose a workflow to scale the agitation and aeration regimes.
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