Search results for " scalability"
Poster
Adenovirus production in a single-use stirring tank bioreactor system
Adenovirus vectors are attractive delivery systems for vaccines and cancer treatment. Scalable and cost-efficient production technologies are needed to enable manufacturing of safe and efficacious c…
Article
Witnessing Major Growth in Next-Generation Antibodies
It is necessary, he adds, to be able to show both scalability and manufacturability, particularly that these products can be produced in large quantities with relative ease in order to meet the treatm…
Poster
FlexFactory™ Automation
FlexFactory Automation is developed and verified to enable efficient design of facilities for development
and manufacturing of biopharmaceuticals. This automation platform is the foundation of th…
Article
Improving Process-Scale Chromatography
Both Cytiva and Pall have systems based on countercurrent processing and are collaborating with customers to demonstrate the scalability of their technologies.
Developments from Cytiva include the…
Poster
Scale-up of CHO fed-batch cultures in HyClone™ ActiPro™ medium supplemented with Cell Boost™ 7a and 7b
In addition, scalability of the culture process was demonstrated in 2 and 50 L bioreactor cultures. Cell density and protein production were shown to be comparable between scales. Protein yields reach…
Article
Generating a Fully Processed Antibody
The authors outline cell-line development and process scale-up for an antibody program in which the antibody requires additional processing by a site-specific enzyme for correct functionality.
B…
Poster
Columns up to 1600 mm in diameter packed with protein A chromatography medium using axial mechanical compression
Axial compression allows for optimally packed beds also in the large-scale chromatography column range. Different methods have been developed to pack a broad range of chromatography media (resins) i…
Article
Continuous Processing for the Production of Biopharmaceuticals
The significant benefits that continuous processing offers—including higher profitability, ease of scalability, and lower manufacturing footprint—make this a topic of interest to every biomanufacturer…
Article
Selecting the Right Viral Clearance Technology
By Cynthia Challener, PhD
The introduction of adventitious viral agents is a recognized, inherent risk of biologic drug production that is well addressed by international regulatory requirements…
Article
Antibody Fragments and Their Purification by Protein L Affinity Chromatography
Antibodies and related proteins comprise one of the largest and fastest-growing classes of protein pharmaceuticals. A majority of such molecules are monoclonal antibodies; however, many new entities…