Search results for " therapeutic" in Articles / App Notes
Article
Innovative Chromatography Resins Can Improve Purity and Quality
Ihre also notes that there continues to be strong demand for new mAbs to address new therapeutic areas and rising requests from customers of contract development and manufacturing organizations (CDMOs…
Article
Gene Therapies Push Viral Vector Production
• AAV exhibits reduced risk of ectopic integration of the therapeutic DNA.
“Adenovirus (AV) was the first viral vector investigated for gene therapy use; however, after the death of a pati…
Article
Can Vaccine Development Be Safely Accelerated?
The company has also developed specific carrier molecules for its mRNA products, including lipid nanoparticles (LNPs), developed in partnership with Acuitas Therapeutics and Arcturus Therapeutics). It…
Article
Best Practices for Selecting a Top-Quality Cell Line
…ular approach to generate high-quality cell lines that meet the production needs of each recombinant therapeutic protein. At the foundation of each cell-line development program, according to Fisch, …
Article
Design Considerations for a Commercial Cell and Gene Therapy Facility
The workflows of a cell therapy or a gene therapy differ from each other and from those of therapeutic antibodies, so the design and layout of the manufacturing facility must take these workflows into…
Article
Addressing the Complex Nature of Downstream Processing with QbD
We have definitely seen therapeutic proteins becoming more complex and have had challenges at times with the downstream process. In one case, we had an engineered antibody, which possessed properties …
Article
Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
On a therapeutic protein, the composition of these glycans can significantly impact the drug’s stability, pharmacokinetics, and biological activity. Thus, glycan structure is a critical quality attrib…
Article
Ensuring Viral Safety of Viral Vaccines and Vectors
Moreover, conditions should be adjusted to avoid aggregation or complex formation of therapeutic viruses and, thus, product loss.
Chromatographic methods are potentially effective tools for adv…
Article
The Challenge of Disruptive Technologies in Bioprocessing
… processes for these new modalities, while meeting the high quality and regulatory standards for the therapeutic,” says Terova.
The biomolecule purification scheme can be very complex, particu…
Article
Biopharma Seeks Balance
Wessel, Emerging Therapeutic Company Investment Deals and Trends, Report, Biotechnology Innovation Organization, May 17, 2018.
Gene therapies offer the potential to …