Search results for " therapeutic" in Articles / App Notes
Article
Improvements in Protein A Chromatography
Bolton recently published a paper “Role of more than 40 years of improvement in Protein A chromatography in the growth of the therapeutic antibody industry,” and also presented at the spring ACS meeti…
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
This specificity is of particular relevance to the production of biotech therapeutics, which require high standards of purity. However, development and optimization of a process chromatography step pr…
Article
Drug Quality Key to Innovation and Access
These issues were highly visible in the debate over FDA approval of Sarepta Therapeutics’ treatment for Duchenne muscular dystrophy; reviewers and senior staffers in the Center for Drug Evaluation and…
Article
A Platform Approach to Purification of Antibody Fragments
As compared with full length antibodies, their fragments have unique properties that make them favorable for certain therapeutic conditions. However, due to their high molecular diversity, the use of …
Article
Generating a Fully Processed Antibody
If a modifying enzyme is required in the process, a sufficient level of the enzyme is needed to fully modify the therapeutic protein; however, too much expression may affect cell growth or other cell …
Article
Affinity Chromatography Handbook: Vol. 1 Antibodies
The diversity of the antibody-antigen interaction and our ability to manipulate the characteristics of the interaction has created many uses for antibodies and antibody fragments, both for immunoche…
Article
A Platform Approach for the Identity Testing of Multi-Component Cell-Culture Media
In the past few years, there has been an increase in the number of therapeutic proteins in development and those that have received approval from regulatory agencies. Proteins are produced by gene exp…
Article
Vaccine Development Faces Urgency and Challenges
Global outbreaks energize vaccine R&D and drive production modernization.
By Jill Wechsler
The Ebola outbreak in 2015 and the current stampede to develop a new vaccine to combat the Zika vir…
Article
Framing Biopharma Success in 2016
The authors suggest that focusing R&D efforts on stable therapy areas and specialty therapeutics will add to scientific, regulatory, and commercial value propositions. Agility, flexibility, and a focu…
Article
Tools for Continuous Bioprocessing Development
have used microfluidic perfusion devices to study therapeutic protein production using Pichia pastoris (30). A perfusion filter (polyethersulfone) with a 1-cm diameter was incorporated underneath the …