Search results for "antibodies" in Articles / App Notes
Article
Witnessing Major Growth in Next-Generation Antibodies
Challener
Next-generation antibodies are designed to be more specific and are often more potent than traditional monoclonal antibodies (mAbs). As a result, their commercial potential is significan…
Article
Antibody Production in Microbial Hosts
Rathore, Jyoti Batra
The biopharmaceutical industry is growing exponentially, driven by an ever-increasing demand for monoclonal antibodies (mAbs) and related products that are capable of treating…
Article
Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
By Robert Karlsson
Abstract
Biotherapeutic antibodies are still the largest growing class of medicines and are used globally to treat a wide range of diseases such as cancer, asthma, and rheum…
Article
Single-Domain Antibodies for Brain Targeting
Smaller recombinant antibody fragments as single-domain antibodies (sdAbs) are emerging as credible alternatives because of their target specificity, high affinity, and cost-effective recombinant prod…
Article
Generating a Fully Processed Antibody
Expression of tagged antibodies in the FGE clonal cell line
The selected FGE line was used as the base cell line to express two different antibodies. The two antibodies bind to different targets w…
Article
HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
ABSTRACT
Monoclonal antibodies represent a significant portion of sales in the biopharmaceuticals market. Ever-growing biotechnology pipelines have greatly increased demand for higher throughput, …
Article
The Development and Application of a Monoclonal Antibody Purification Platform
The following article describes the development of a purification platform for monoclonal antibodies (MAbs) at Pfizer's Global Biologics division, including how the individual unit operations have bee…
Article
Chromatography for the Diversified Antibody Pipeline
Eva Helding: The antibodies are one of the largest classes of biomolecules and there are several approved drugs—the first approved drug was in 1986. The antibodies have been there; however, we have al…
Article
Comparing Protein A Resins for Monoclonal Antibody Purification
The methodology for the production of monoclonal antibodies from a cell line by hybridization of mouse myeloma and mouse spleen cells from an immunized donor was first published in 1975 (1). As a tech…
Article
Top Tips for Successful Development of Antibody Chromatography Processes
If we look back a couple of years, we saw that the main antibody group was monoclonal antibodies. But today, it's a lot more diverse. We see more fragments, such as Fabs, scFv fusion proteins, domain …