Search results for " perfusion"
Article
Integrated Semi-Continuous Process for mAb Production
Linking these different steps together to a fully continuous process can be a challenging task, and studies in the area of continuous processes typically deals with single unit operations, such as per…
Article
Bioprocessing Advances in Vaccine Manufacture
This includes perfusion. Capillary hollow-fiber perfusion bioreactors being developed by FiberCell Systems, for example, are expected to comparably produce up to 1000 x (based on bioreactor size) the …
Webcast
Webinar: Building an Innovative Integrated Continuous Downstream Manufacturing Platform for the Production of Biologics
It involves dealing with variable perfusion flow rate, normalization of dynamic perfusion titer profile, sizing between intermittent (bind-elute chromatography) and continuous (viral inactivation) uni…
Article
Digitalization: The Route to Biopharma 4.0
Semi-Continuous Scale-Down Models for Clone and Operating Parameter Screening in Perfusion Bioreactors. Biotechnol Prog. 2019, 35 (3), e2790. DOI: 10.1002/btpr.2790.
5. Wolf, M.; Bielser, J. M.;…
Article
Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
In FBRs, nutrients and gasses are provided to the cells through circulation or perfusion of the medium through the fixed bed while the cells are immobilized. The cells are only in contact with the imp…
Article
Start-to-Finish Connected Manufacturing
That’s why we are demonstrating our mAb process that tested the performance of a new Xcellerex automatic perfusion system (APS) bioreactor, compared resin and fiber-based chromatography, and utilized …
Article
The New World of Biopharmaceutical Manufacturing
Levison (Pall): The real bottleneck is in the upstream (cell culture), which is why there is so much interest in perfusion technologies for continuous cell culture. Bioprocesses cannot be fully contin…
Poster
One-step seed culture expansion from one vial of high-density cell bank to 2000 L production bioreactor
This application note describes how perfusion cell culturing can be used to reduce processing time, simplify operations, and maximize equipment utilization in seed culture expansion processes.
Article
Paring Down Impurities in Downstream Processing
Bioreactors to house these systems might be stirred-tank, air-lift, fixed-bed, hollow-fiber perfusion, or suspension, perhaps even hybrid combinations thereof. All of these lead to a gamut of membrane…
Article
Report from the 6th International HTPD Conference
…xing in individual cells on the plate has evolved, along with case studies on microwell-based pseudo perfusion bioreactors. The presentation concluded with an outlook of future research areas which i…